INT229562

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.70
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxp3) intracellular (Foxp3) embryo development (Foxp3)
DNA binding (Foxp3) cytoplasm (Foxp3)
Anatomy Link Frequency
macrophage 1
T cells 1
Foxp3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 24 99.90 Very High Very High Very High
Inflammation 26 99.02 Very High Very High Very High
Multiple sclerosis 41 98.68 Very High Very High Very High
Crohn's disease 1 96.88 Very High Very High Very High
Neuropeptide 39 89.68 High High
Central nervous system 61 88.40 High High
spinal inflammation 1 86.00 High High
tolerance 16 84.48 Quite High
Spinal cord 5 5.00 Very Low Very Low Very Low
Substantia nigra 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 34 99.02 Very High Very High Very High
Multiple Sclerosis 78 98.68 Very High Very High Very High
Disease 51 98.44 Very High Very High Very High
Demyelinating Disease 8 97.36 Very High Very High Very High
Cancer 319 93.16 High High
Brain Tumor 22 89.84 High High
Diabetes Mellitus 48 85.64 High High
Immunization 41 82.08 Quite High
Glioma 18 69.84 Quite High
Autoimmune Disease 37 68.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mediated Foxp3 was inhibited by 1,25(OH)2D3 via the VDR signal on CD4+ T cells (Figure 4).
Negative_regulation (inhibited) of Foxp3 in T cells
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.18 Pain Relevance 0.03
are inflammatory disorders with known Th1-directed cytokines and loss of Foxp3
Negative_regulation (loss) of Foxp3 associated with inflammation and cytokine
2) Confidence 0.36 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2643053 Disease Relevance 1.08 Pain Relevance 0.52
production by this population, although FOXP3 levels were reduced within the CD4+CD25+ population after anti-CD3/CD28 stimulation (Fig. 6a).
Negative_regulation (reduced) of FOXP3
3) Confidence 0.30 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.37 Pain Relevance 0.08
However, Foxp3 is intranuclear and therefore cannot be easily depleted using immunoglobulins.
Negative_regulation (depleted) of Foxp3
4) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.39 Pain Relevance 0
In agreement with others, our data indicate that systemic delivery of PC61 causes the depletion of Foxp3+ Tregs [25], [33], [35].
Negative_regulation (depletion) of Foxp3
5) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.64 Pain Relevance 0
For example, CrohnÂ’s disease (CD) and MS are inflammatory disorders with known Th1-directed cytokines and loss of Foxp3 Treg function.33,34 In one study in MS patients Treg numbers were unchanged but their function may have been diminished.92 As VRS have important roles in controlling macrophage and perivascular infiltrates in MS,35 VRS immunological function in relation to VNs becomes of considerable interest.
Negative_regulation (loss) of Foxp3 in macrophage associated with multiple sclerosis, inflammation, neuropeptide, disease and cytokine
6) Confidence 0.16 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.04 Pain Relevance 0.52

General Comments

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