INT229573

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.46
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Kit) cell differentiation (Kit) extracellular space (Kit)
plasma membrane (Kit) nucleus (Kit) kinase activity (Kit)
Anatomy Link Frequency
blood 2
mast cell 2
Kit (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2 94.24 High High
cytokine 10 93.20 High High
ischemia 47 50.00 Quite Low
Pain 9 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain score 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 86 99.98 Very High Very High Very High
INFLAMMATION 3 94.24 High High
Mastocytosis 48 92.32 High High
Hematological Disease 5 87.20 High High
Parasitemia 13 84.92 Quite High
Thrombocytopenia 3 83.36 Quite High
Cutaneous Mastocytosis 7 72.64 Quite High
Apoptosis 2 66.68 Quite High
Disease 22 58.32 Quite High
Hypergammaglobulinemia 4 53.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In neoplastic mast cell lines, valine or tyrosine substitution for an aspartate in c-kit codon 816 results in constitutive phosphorylation and activation of KIT[6].
Positive_regulation (results) of Positive_regulation (activation) of KIT in mast cell
1) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2292130 Disease Relevance 0.62 Pain Relevance 0
Rather, the infection induces the expression of Sca-1 in a considerable number of ckit?
Positive_regulation (induces) of Positive_regulation (number) of ckit associated with infection
2) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.83 Pain Relevance 0.09
Patel's group reported a "multipotent menstrual blood stromal stem cell" [54], which had an expression profile of Oct-4, c-kit and SSEA-4 positive and negative for expression of hematopoietic markers.
Positive_regulation (had) of Positive_regulation (profile) of c-kit in blood
3) Confidence 0.04 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0 Pain Relevance 0

General Comments

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