INT22962

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Context Info
Confidence 0.58
First Reported 1990
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.32
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (FXYD1)
Anatomy Link Frequency
spinal cord 1
FXYD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 1 99.36 Very High Very High Very High
Spinal cord 6 97.96 Very High Very High Very High
anesthesia 5 96.76 Very High Very High Very High
Pain 30 93.84 High High
epidural 2 75.00 Quite High
anticonvulsant 3 73.04 Quite High
Paresthesia 3 37.28 Quite Low
peripheral neuropathy 24 24.24 Low Low
Dopamine 57 5.00 Very Low Very Low Very Low
agonist 57 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Akathisia 48 99.90 Very High Very High Very High
Myoclonus 8 99.20 Very High Very High Very High
Restless Legs Syndrome 504 98.48 Very High Very High Very High
Sleep Disorders 75 97.04 Very High Very High Very High
Obstructive Sleep Apnea 3 96.56 Very High Very High Very High
Cramps 6 95.92 Very High Very High Very High
Sleep-wake Transition Disorders 3 93.52 High High
Pain 9 92.12 High High
Anxiety Disorder 3 83.68 Quite High
Syndrome 6 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our two cases, PLM were seen only while the local anesthetic was acting on the spinal cord; therefore, these anesthesia-related PLM (ARPLM) may suggest that the spinal cord is involved.
Gene_expression (seen) of PLM in spinal cord associated with anesthesia, spinal cord and local anesthetic
1) Confidence 0.58 Published 1990 Journal Sleep Section Abstract Doc Link 2356397 Disease Relevance 0.45 Pain Relevance 0.70
Motor restlessness and PLM are not present.
Neg (not) Gene_expression (present) of PLM associated with akathisia
2) Confidence 0.08 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695234 Disease Relevance 1.12 Pain Relevance 0.38
Associated sensory discomfort and PLM are not present.


Neg (not) Gene_expression (present) of PLM
3) Confidence 0.08 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695234 Disease Relevance 1.04 Pain Relevance 0.04
PLM detection is based on neurophysiological techniques, usually on polysomnography.
Gene_expression (detection) of PLM
4) Confidence 0.07 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695234 Disease Relevance 0.72 Pain Relevance 0

General Comments

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