INT22966

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Context Info
Confidence 0.50
First Reported 1990
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.03
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
connective tissue 2
Pah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 20 99.10 Very High Very High Very High
cva 7 98.36 Very High Very High Very High
antagonist 9 59.32 Quite High
fibrosis 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 162 100.00 Very High Very High Very High
Eisenmenger Complex 5 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 99.98 Very High Very High Very High
Disease 19 99.58 Very High Very High Very High
Toxicity 6 99.28 Very High Very High Very High
Nephrotoxicity 7 98.82 Very High Very High Very High
Cv General 3 Under Development 4 98.36 Very High Very High Very High
Systemic Sclerosis 16 96.92 Very High Very High Very High
Increased Venous Pressure Under Development 9 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to APAP nephrotoxicity in vivo, APAP toxicity in renal slices was accompanied by decreased accumulation of PAH and TEA.
Negative_regulation (decreased) of Positive_regulation (accumulation) of PAH associated with nephrotoxicity, toxicity and paracetamol
1) Confidence 0.50 Published 1990 Journal Toxicol. Lett. Section Abstract Doc Link 2356566 Disease Relevance 0.79 Pain Relevance 1.48
Bosentan has been extensively used as monotherapy in PAH especially in patients with idiopathic PAH and scleroderma associated PAH but also appears to be efficacious in other forms of pulmonary hypertension including other connective tissue disease associated PAH, HIV associated PAH and Eisenmenger syndrome as well as in selected cases of chronic thromboembolic pulmonary hypertension.
Negative_regulation (associated) of Positive_regulation (syndrome) of PAH in connective tissue associated with pulmonary hypertension, eisenmenger complex, acquired immune deficiency syndrome or hiv infection, cva, disease and systemic sclerosis
2) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350123 Disease Relevance 1.25 Pain Relevance 0.08

General Comments

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