INT229679

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.64
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Plec) plasma membrane (Plec) cytoskeleton (Plec)
cytoplasm (Plec)
Plec (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 136 97.86 Very High Very High Very High
Kinase C 2 76.24 Quite High
antagonist 22 55.00 Quite High
Inflammation 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 198 98.64 Very High Very High Very High
Bullous Skin Disease 2 97.52 Very High Very High Very High
Cancer 102 95.40 Very High Very High Very High
Castlemans Disease 2 95.00 High High
Embryonal Carcinoma 23 94.48 High High
Disease Progression 4 91.92 High High
Disease 14 82.32 Quite High
Adhesions 1 72.64 Quite High
Metaplasia 12 70.28 Quite High
Pancreatic Cancer 42 59.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to the development of novel molecularly targeted imaging agents, phage display screening and modified immunoprecipitation permitted the identification of membrane-localized plectin-1 as a potential new biomarker for PDAC.
Localization (localized) of plectin-1 associated with adenocarcinoma and imagery
1) Confidence 0.65 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2292750 Disease Relevance 0.69 Pain Relevance 0.26
Altered subcellular localization of plectin-1 is also observed in the autoimmune condition, paraneoplastic pemphigus, and in the associated lymphoproliferative neoplasm, Castleman disease [33].
Localization (localization) of plectin-1 associated with cancer, castlemans disease and bullous skin disease
2) Confidence 0.65 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2292750 Disease Relevance 0.78 Pain Relevance 0.07
At day 10, EBs were fixed in 5% formaldehyde at room temperature for 30 minutes, and then permeabilized with 0.2% Triton X-100 in PBS.
Localization (permeabilized) of EBs
3) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483414 Disease Relevance 0 Pain Relevance 0
OT-GKR peptide levels in media secreted from control EBs at day 5 were 211.9±62.5 pg/ml whereas the corresponding values obtained in media from OT-GKR-transfected cells disclosed a significant increment of peptide concentration to 581.3±41.5 pg/ml (n?
Localization (secreted) of EBs
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.17 Pain Relevance 0.03

General Comments

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