INT229710

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 0.57
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Agtr1a) aging (Agtr1a) Golgi apparatus (Agtr1a)
plasma membrane (Agtr1a) cytoplasm (Agtr1a) signal transducer activity (Agtr1a)
Anatomy Link Frequency
brain 4
retina 1
cerebellum 1
Agtr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 6 99.08 Very High Very High Very High
medulla 6 95.40 Very High Very High Very High
amygdala 6 94.24 High High
Pyramidal cell 36 90.04 High High
adenocard 37 86.32 High High
Pain 7 78.08 Quite High
Hippocampus 36 57.52 Quite High
Bioavailability 1 55.04 Quite High
fibrosis 1 53.76 Quite High
Inflammation 3 52.72 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 99.68 Very High Very High Very High
Increased Venous Pressure Under Development 9 84.96 Quite High
Pain 7 78.08 Quite High
Cardiovascular Disease 3 68.24 Quite High
Cirrhosis 1 65.12 Quite High
Cancer 1 63.52 Quite High
Fibrosis 1 53.76 Quite High
INFLAMMATION 3 52.72 Quite High
Hypertension 52 50.00 Quite Low
Apoptosis 3 32.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Telmisartan blunts all the AT1-mediated effect of angiotensin II, including the vasoconstrictor and aldosterone-secreting effect of angiotensin II.
Localization (secreting) of AT1
1) Confidence 0.60 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2293961 Disease Relevance 0 Pain Relevance 0.03
AT1 receptors have been localized to the ganglion cell layer and inner nuclear layer in rat retina (Wheeler-Schilling et al 1999).
Localization (localized) of AT1 in retina associated with ganglion cysts
2) Confidence 0.12 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 0.49 Pain Relevance 0.05
Co-localization of A1R and P2Y2R in transfected HEK293T cells
Localization (localization) of A1R
3) Confidence 0.02 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.04
Importantly, co-localization of A1R and P2Y2R in the cerebellum was observed in cell bodies, except in the nuclear region, in the Purkinje cells and those of the interposed cerebellar lobule nucleus (Figure 2D-I).
Localization (localization) of A1R in cerebellum
4) Confidence 0.02 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.21
In the present study, we visualized the surface expression and co-localization of A1R and P2Y2R in both transfected HEK293T cells and in rat brain by confocal microscopy and more precisely by immunogold electron microscopy.
Localization (localization) of A1R in brain
5) Confidence 0.02 Published 2010 Journal BMC Res Notes Section Abstract Doc Link PMC3009664 Disease Relevance 0.08 Pain Relevance 0.24
The co-localization of A1R and P2Y2R in co-transfected HEK293T cells was examined by double immunostaining of HA-A1R and Myc-P2Y2R as a comparison experiment for the localization of these receptors in brain tissues (Figure 2).
Localization (localization) of A1R in brain
6) Confidence 0.02 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.04
Immunogold electron microscopic observations of A1R and P2Y2R expressed in rat brain
Localization (observations) of A1R in brain
7) Confidence 0.01 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0
Co-immunoprecipitation of A1R and P2Y2R from rat brain
Localization (immunoprecipitation) of A1R in brain
8) Confidence 0.01 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.23

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