INT22973

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Context Info
Confidence 0.42
First Reported 1990
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 22
Total Number 25
Disease Relevance 15.85
Pain Relevance 4.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col3a1) extracellular region (Col3a1)
Anatomy Link Frequency
smooth muscle 2
tendon cells 1
extracellular matrix 1
epithelial cell 1
bladders 1
Col3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 81 100.00 Very High Very High Very High
metalloproteinase 17 100.00 Very High Very High Very High
Fibrositis 8 99.56 Very High Very High Very High
Chronic pancreatitis 27 98.96 Very High Very High Very High
COX-2 inhibitor 4 98.76 Very High Very High Very High
methotrexate 55 94.40 High High
Inflammation 108 92.64 High High
intrathecal 1 90.48 High High
qutenza 1 88.52 High High
cINOD 5 88.36 High High
Disease Link Frequency Relevance Heat
Fibrosis 90 100.00 Very High Very High Very High
Adhesions 13 100.00 Very High Very High Very High
Fibromyalgia 5 99.56 Very High Very High Very High
Adult Respiratory Distress Syndrome 115 99.32 Very High Very High Very High
Anastomotic Leak 4 99.28 Very High Very High Very High
Pancreatitis 29 98.96 Very High Very High Very High
Hypertension 46 98.56 Very High Very High Very High
Stress 187 98.32 Very High Very High Very High
Pulmonary Edema 7 98.20 Very High Very High Very High
Coronary Heart Disease 2 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the expression of types I and III collagen remained unchanged.
Gene_expression (expression) of III collagen
1) Confidence 0.42 Published 2007 Journal Connect. Tissue Res. Section Abstract Doc Link 17364667 Disease Relevance 0 Pain Relevance 0.03
However, both RT-PCR and immunocytochemical staining revealed that mRNA and protein expression of types I and III collagen remained constant after celecoxib treatment.
Gene_expression (expression) of III collagen
2) Confidence 0.42 Published 2007 Journal Connect. Tissue Res. Section Abstract Doc Link 17364667 Disease Relevance 0.11 Pain Relevance 0.09
The protein expression of types I and III collagen were determined by immunocytochemistry.
Spec (determined) Gene_expression (expression) of III collagen
3) Confidence 0.42 Published 2007 Journal Connect. Tissue Res. Section Abstract Doc Link 17364667 Disease Relevance 0.14 Pain Relevance 0.11
Serum concentrations of procollagen type III aminoterminal peptide have previously been reported to be low in some patients with primary fibromyalgia and the aim of this study was to determine if such patients differ clinically from primary fibromyalgia patients with normal levels of procollagen type III aminoterminal peptide.
Gene_expression (levels) of procollagen type III aminoterminal peptide associated with fibrositis
4) Confidence 0.40 Published 1990 Journal Br. J. Rheumatol. Section Abstract Doc Link 2357497 Disease Relevance 0.37 Pain Relevance 0.18
Type III collagen synthesis and the rate of mandibular growth were strongly related through all ages studied.
Gene_expression (synthesis) of Type III collagen
5) Confidence 0.39 Published 1993 Journal Arch. Oral Biol. Section Abstract Doc Link 8343068 Disease Relevance 0.13 Pain Relevance 0.07
This study was designed to determine the effects of COX-2 inhibitor (celecoxib) on the migration, proliferation, and types I and III collagen expression of tendon cells intrinsic to rat Achilles tendon.
Gene_expression (expression) of III collagen in tendon cells associated with cox-2 inhibitor
6) Confidence 0.32 Published 2007 Journal Connect. Tissue Res. Section Abstract Doc Link 17364667 Disease Relevance 0.17 Pain Relevance 0.14
Immunohistochemistry revealed the expression of fibronectin and collagen types I and III.
Gene_expression (expression) of collagen types I and III
7) Confidence 0.30 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16959955 Disease Relevance 1.28 Pain Relevance 0.41
Morphometric studies on animal or human bladder strips have demonstrated an increased expression of proteolytic enzymes and endogenous tissue inhibitors of metalloproteinases (MMP-1) and type III collagen mRNA in hypocompliant neurogenic bladders.
Gene_expression (expression) of type III collagen mRNA in bladders associated with metalloproteinase
8) Confidence 0.30 Published 2004 Journal Prog. Urol. Section Abstract Doc Link 15776894 Disease Relevance 0.47 Pain Relevance 0.26
The expression of collagen type III also significantly increased according to the number of days of stress exposure.

3.

Gene_expression (expression) of collagen type III associated with stress
9) Confidence 0.24 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855479 Disease Relevance 1.05 Pain Relevance 0
But, Collagen type I and type III mRNA expression levels in the infarcted area of AdV.SDF-1 group were lower than the control group or AdV.LacZ group (Fig. 4c, d).
Gene_expression (expression) of Collagen type I and type III mRNA
10) Confidence 0.20 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.30 Pain Relevance 0
Collagen type I and type III mRNA expression levels in the infarcted area of AdV.SDF-1 group, control group and AdV.LacZ group increased obviously compared to that of sham-operated rats.
Gene_expression (expression) of Collagen type I and type III mRNA
11) Confidence 0.20 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.24 Pain Relevance 0
In the expression of collagen type III, there were significant differences in the 7-day and 28-day stress groups, with p-values of p=0.015 and p=0.021, respectively (Fig. 3B).

4.

Gene_expression (expression) of collagen type III associated with stress
12) Confidence 0.18 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855479 Disease Relevance 1.29 Pain Relevance 0
As a result, the EAM60 group rats showed significantly increased expression of collagen type I and III, mainly type I, in myocardial interstitium, compared with the control group.
Gene_expression (expression) of collagen type I and III
13) Confidence 0.18 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768010 Disease Relevance 0.51 Pain Relevance 0.35
Renal levels of TGF-beta1 and -beta2, alpha-actin, type III collagen, and fibronectin mRNA decreased in rats treated with anti-TGF-beta Ab.
Gene_expression (levels) of type III collagen
14) Confidence 0.17 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12185011 Disease Relevance 0.72 Pain Relevance 0.04
Furthermore, the expression of collagen type I and type III mRNA, and collagen accumulation in the infarcted area was lower, which was associated with decreased TGF-?
Gene_expression (expression) of collagen type I and type III mRNA
15) Confidence 0.17 Published 2009 Journal Mol Biol Rep Section Abstract Doc Link PMC2831180 Disease Relevance 0.44 Pain Relevance 0
Pancreata were histopathologically examined at every 4 weeks, and the expression of fibrosis-related factors such as transforming growth factor beta1 (TGF-beta1), fibronectin (FN), alpha-smooth muscle actin (alpha-SMA), and type III collagen was analyzed.
Spec (analyzed) Gene_expression (expression) of type III collagen in smooth muscle associated with fibrosis
16) Confidence 0.16 Published 2001 Journal Pancreas Section Abstract Doc Link 11138977 Disease Relevance 0.88 Pain Relevance 0.60
However, in the TJ-10-treated rats, the rate of pancreatic fibrosis and the expression of TGF-beta1, FN, alpha-SMA, and type III collagen at 12 and 16 weeks decreased significantly compared to those in the untreated rats.
Gene_expression (expression) of type III collagen associated with fibrosis
17) Confidence 0.13 Published 2001 Journal Pancreas Section Abstract Doc Link 11138977 Disease Relevance 0.80 Pain Relevance 0.56
Effects of overinflation on procollagen type III expression in experimental acute lung injury

Introduction

Gene_expression (expression) of procollagen type III in lung associated with adult respiratory distress syndrome
18) Confidence 0.11 Published 2007 Journal Crit Care Section Title Doc Link PMC2151905 Disease Relevance 0.47 Pain Relevance 0
IFN-gamma was localized to acinar, infiltrating and ductal cells, and its expression intensity showed significant correlation with those of fibrosis, type III collagen and alpha-smooth muscle actin.
Gene_expression (expression) of type III collagen in smooth muscle associated with fibrosis
19) Confidence 0.08 Published 2001 Journal Pancreas Section Abstract Doc Link 11345142 Disease Relevance 1.02 Pain Relevance 0.67
, caspase-3, type III procollagen (PCIII), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) mRNA expressions in lung tissue, as well as lung and distal organ epithelial cell apoptosis in an experimental model of sepsis-induced ALI.


Gene_expression (expressions) of type III procollagen in epithelial cell associated with adult respiratory distress syndrome, apoptosis, sepsis and adhesions
20) Confidence 0.08 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.74 Pain Relevance 0

General Comments

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