INT229750

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 9.38
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CHDH)
CHDH (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 4 63.08 Quite High
Angina 42 39.64 Quite Low
aspirin 8 32.00 Quite Low
ischemia 15 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 697 100.00 Very High Very High Very High
Coronary Artery Disease 308 100.00 Very High Very High Very High
Death 43 100.00 Very High Very High Very High
Sudden Death 1 100.00 Very High Very High Very High
Obesity 50 98.08 Very High Very High Very High
Overweight 9 97.48 Very High Very High Very High
Cardiovascular Disease 85 92.72 High High
Nicotine Addiction 60 92.32 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 91.80 High High
Disease 32 63.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The harms of CHD risk calculation
Positive_regulation (calculation) of Gene_expression (risk) of CHD associated with coronary artery disease
1) Confidence 0.30 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2294118 Disease Relevance 0.87 Pain Relevance 0
In our search for articles about the benefits of physician knowledge of global CHD risk scores, we excluded studies for the following reasons: (1) studies were unrelated to global CHD risk calculation; (2) they calculated the risk scores for the secondary prevention of CHD risk; (3) they answered the wrong question about CHD risk scores (e.g. they were related to development and validation of risk scores; the conceptual understanding of risk scores; the accuracy of risk perception; the accuracy of systems to calculate CHD risk; or the acceptability of decision aids including CHD risk); (4) they used risk scores for the wrong use (e.g. as part of the eligibility criteria or endpoints of a study, but not as information for physicians); (5) they were about the benefits of CHD risk scores, but did not have a quantitative experimental design (e.g. reviews, editorials, qualitative studies, methods papers); (6) they used a non-controlled experimental design (e.g. pre-post designs); (7) they focused on the effects of patient knowledge of CHD risk scores; or (8) they administered global risk as part of a mixed intervention without the ability to determine the independent effect of the risk score.
Positive_regulation (related) of Gene_expression (scores) of CHD associated with coronary artery disease and acquired immune deficiency syndrome or hiv infection
2) Confidence 0.30 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2294118 Disease Relevance 1.12 Pain Relevance 0.03
Associations were of a similar magnitude for prevalent CHD (CRP levels measured at same time as history of CHD ascertained) and incident CHD (CRP levels measured before new cases of CHD) in each cohort, and with a combined outcome of prevalent and incident CHD.
Positive_regulation (incident) of Gene_expression (levels) of CHD associated with cv unclassified under development
3) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 1.07 Pain Relevance 0
That study suggested that there was no strong evidence for a causal association between CRP levels and CHD but the authors acknowledged that pooling of larger studies was required to increase confidence in this conclusion.[12] A number of other studies, which have not directly employed Mendelian randomization approaches and have included between 210 to 1062 CHD cases, have also found genetic variants within the CRP gene to be unrelated to prevalent and incident CHD events, despite these variants being associated with CRP levels.[13]–[17]
Positive_regulation (unrelated) of Gene_expression (events) of CHD associated with cv unclassified under development
4) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 1.05 Pain Relevance 0
We estimated the association of CRP genetic variant +1444C>T (rs1130864) with CRP levels and with CHD in five studies and then pooled these analyses (N?
Positive_regulation (with) of Gene_expression (levels) of CHD associated with cv unclassified under development
5) Confidence 0.15 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507759 Disease Relevance 0.68 Pain Relevance 0
We estimated the association of CRP genetic variant +1444C>T (rs1130864) with CRP levels and with CHD in five studies and then pooled these analyses (N?
Positive_regulation (with) of Gene_expression (levels) of CHD associated with cv unclassified under development
6) Confidence 0.15 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507759 Disease Relevance 0.68 Pain Relevance 0
Associations were of a similar magnitude for prevalent CHD (CRP levels measured at same time as history of CHD ascertained) and incident CHD (CRP levels measured before new cases of CHD) in each cohort, and with a combined outcome of prevalent and incident CHD.
Positive_regulation (prevalent) of Gene_expression (levels) of CHD associated with cv unclassified under development
7) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 1.08 Pain Relevance 0
A figure of 3.3 was used for the RR for CHD death or sudden death in those with existing CHD, taken from the Framingham study. [21]
Positive_regulation (used) of Gene_expression (existing) of CHD associated with coronary artery disease, sudden death and death
8) Confidence 0.13 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 2.03 Pain Relevance 0
Pooled estimate of CHD odds ratios were calculated from published studies for the PPARG Ala12Pro SNP including 6898 cases and 11?
Positive_regulation (estimate) of Gene_expression (ratios) of CHD associated with coronary artery disease
9) Confidence 0.12 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 0.74 Pain Relevance 0

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