INT229787

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.94
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (AGXT) small molecule metabolic process (AGXT) peroxisome (AGXT)
cellular nitrogen compound metabolic process (AGXT)
AGXT (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 60 98.72 Very High Very High Very High
antagonist 12 93.60 High High
b2 receptor 6 93.16 High High
adenocard 124 89.60 High High
Hsan 94 82.40 Quite High
bradykinin 82 77.76 Quite High
Bile 18 71.52 Quite High
Inflammation 28 68.40 Quite High
Inflammatory response 4 40.88 Quite Low
isoflurane 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 1 94.96 High High
Peripheral Neuropathy 1 85.56 High High
Hereditary Sensory And Autonomic Neuropathies 101 82.40 Quite High
Hypoxia 16 80.48 Quite High
Injury 8 70.24 Quite High
INFLAMMATION 32 68.40 Quite High
Neuropathic Pain 13 52.16 Quite High
Pressure And Volume Under Development 2 38.24 Quite Low
Disorder Of Lipid Metabolism 28 15.56 Low Low
Obesity 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of sphingolipid synthesis at the SPT step prevents a harmful accumulation of metabolic sphingolipid-intermediates including sphingoid bases and ceramide, whereas repression of other anabolic steps in the spingolipid synthetic pathway may cause intermediates to accumulate.
Gene_expression (synthesis) of SPT associated with repression
1) Confidence 0.16 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2311280 Disease Relevance 0.47 Pain Relevance 0.24
activation decreases hepatic aminotransferase expression in mice, PPAR?
Gene_expression (expression) of hepatic aminotransferase
2) Confidence 0.10 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.20 Pain Relevance 0.15
governs metabolism of amino acids by suppressing expression of genes involved in transamination (Aspartate amino transferase (Got1), Alanine amino transferase (Gpt), Alanine glyoxylate aminotransferase (Agtx2), and deamination (Glutaminase (Gls)), as well as numerous genes that are part of the urea cycle (Cps1, Otc, Ass1, and Asl) [160, 161, 245].
Gene_expression (expression) of Alanine glyoxylate aminotransferase
3) Confidence 0.08 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0 Pain Relevance 0.14
Desflurane-induced enhanced recovery of FoC at the end of reoxygenation was abolished (P < 0.0001) in presence of MPG (FoC60: 54 ± 3% of baseline), SPT (FoC60: 62 ± 9% of baseline), HOE 140 (FoC60: 58 ± 6% of baseline).
Gene_expression (presence) of SPT
4) Confidence 0.05 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.21 Pain Relevance 0.16
The effect of MPG, SPT, and HOE140 alone was studied in separate groups exposed to 150 ?
Gene_expression (alone) of SPT
5) Confidence 0.05 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.06 Pain Relevance 0.38

General Comments

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