INT229855

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.30
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp7) peptidase activity (Casp7) aging (Casp7)
cytoplasm (Casp7)
Anatomy Link Frequency
retinas 1
Casp7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 98 99.34 Very High Very High Very High
cINOD 12 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Cholecystokinin 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 122 99.70 Very High Very High Very High
Cv Unclassified Under Development 35 99.34 Very High Very High Very High
Retina Disease 51 98.06 Very High Very High Very High
Ocular Hypertension 24 62.88 Quite High
Stress 23 53.20 Quite High
Death 21 38.04 Quite Low
Injury 15 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 12 5.00 Very Low Very Low Very Low
Infection 12 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further investigate the impact of retinal ischemia on downstream effectors of apoptosis stimulated by members of the Bcl-2 family, we analyzed the expression of caspase-3 and caspase-7 by qPCR.
Spec (analyzed) Gene_expression (expression) of caspase-7 associated with ischemia, apoptosis and retina disease
1) Confidence 0.28 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.60 Pain Relevance 0.12
Analysis of caspases associated with mitochondria-mediated apoptosis revealed a specific increase in the expression of caspase-3 in the ischemic retinas 24 h after reperfusion, and a decrease in the expression of caspase-7.


Gene_expression (expression) of caspase-7 in retinas associated with apoptosis
2) Confidence 0.22 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2765238 Disease Relevance 0.55 Pain Relevance 0.16
Ischemia-induced caspase-3 and repressed caspase-7 mRNAs expression 24 h after I/R
Gene_expression (expression) of caspase-7 associated with ischemia
3) Confidence 0.21 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.44 Pain Relevance 0.10
Although some pro-apoptotic genes were mildly affected (eg Bax, Caspase 7), no changes were seen in many key pro-apoptotic genes such as Bad, Caspase 3 and Apaf1.
Gene_expression (affected) of Caspase 7 associated with apoptosis
4) Confidence 0.17 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2311291 Disease Relevance 0.38 Pain Relevance 0
In addition, some markers of apoptosis were slightly affected (Bak, Caspase 7), while most (including Apaf, Caspase 9, caspase 3, caspase 2, Bcl2 and Bad) were not affected by FOS.


Gene_expression (affected) of Caspase 7 associated with apoptosis
5) Confidence 0.17 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2311291 Disease Relevance 0.31 Pain Relevance 0

General Comments

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