INT229892

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.11
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (COQ10A)
Anatomy Link Frequency
mononuclear cells 2
COQ10A (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 58 98.76 Very High Very High Very High
depression 5 82.96 Quite High
headache 1 81.52 Quite High
chronic pain syndrome 2 79.28 Quite High
Bioavailability 3 54.80 Quite High
Pain 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
sSRI 1 5.00 Very Low Very Low Very Low
central sensitization 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 58 98.76 Very High Very High Very High
Stress 47 96.28 Very High Very High Very High
Aging 1 93.84 High High
Depression 5 82.96 Quite High
Headache 1 81.52 Quite High
Fatigue 7 81.12 Quite High
Complex Regional Pain Syndromes 2 79.28 Quite High
Parkinson's Disease 11 50.00 Quite Low
Disorder Of Lipid Metabolism 6 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the current study, it is evident that intramuscular CoQ10 levels increased following each testing session (T2 Pre to Post and T3 Pre to Post); while the placebo group showed an overall decrease in intramuscular CoQ10 levels (Figure 4).
Positive_regulation (increased) of Gene_expression (levels) of CoQ10
1) Confidence 0.43 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.19 Pain Relevance 0.03
Previously, we detected decreased coenzyme Q10 (CoQ10) levels and increased reactive oxygen species (ROS) production in blood mononuclear cells of FM patients, providing direct evidence of increased oxidative stress at the cellular level [5].
Positive_regulation (increased) of Gene_expression (production) of CoQ10 in mononuclear cells associated with stress and fibrositis
2) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875645 Disease Relevance 0.92 Pain Relevance 0.37

General Comments

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