INT229894

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 2.95
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (COQ10A)
Anatomy Link Frequency
blood 2
muscle 2
COQ10A (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 174 99.92 Very High Very High Very High
Bioavailability 15 94.64 High High
lidocaine 5 71.48 Quite High
depression 15 5.00 Very Low Very Low Very Low
chronic pain syndrome 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Peripheral sensitization 3 5.00 Very Low Very Low Very Low
sSRI 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 174 99.92 Very High Very High Very High
Nociception 6 97.76 Very High Very High Very High
Stress 221 96.08 Very High Very High Very High
Injury 15 84.04 Quite High
Aging 5 71.20 Quite High
Parkinson's Disease 33 59.28 Quite High
Stroke 5 43.88 Quite Low
Hepatocellular Cancer 2 40.36 Quite Low
Disease 21 39.92 Quite Low
Myocardial Infarction 20 39.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CoQ10 is normally localized in the central hydrophobic portion of the membrane and thus, it has been suggested that its concentration may not be able to increase freely within the membrane due to physical limits and potential destabilization of the bilayer structure [35].
Localization (localized) of CoQ10
1) Confidence 0.69 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0 Pain Relevance 0
However, whether a maximal limit and/or down regulation in the transport of CoQ10 into the muscle occurs following chronic CoQ10 supplementation is highly speculative and requires further investigation
Localization (transport) of CoQ10 in muscle
2) Confidence 0.65 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.14 Pain Relevance 0
Therefore, absorption of CoQ10 into tissues is often slow and limited.
Localization (absorption) of CoQ10
3) Confidence 0.65 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.05 Pain Relevance 0.04
CoQ10 determination
Localization (determination) of CoQ10
4) Confidence 0.65 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.07 Pain Relevance 0.07
However, the effects of acute and chronic ingestion of a fast-melt form of CoQ10 on muscle CoQ10 concentrations and exercise performance is unknown.
Localization (form) of CoQ10 in muscle
5) Confidence 0.61 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.07 Pain Relevance 0.08
To elucidate whether autophagy in CoQ10-deficient BMCs could be mitigated by restoring mitochondrial functionality by CoQ10 supplementation, we cultured both control and patient BMCs in the presence of CoQ10 (100 ?
Localization (presence) of CoQ10
6) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875645 Disease Relevance 0.27 Pain Relevance 0.13
-tocopherol; BMCs: blood mononuclear cells; CoQ10: coenzyme Q10; FM: fibromyalgia; MPT: mitochondrial permeability transition; ROS: reactive oxygen species; TBARS: thiobarbituric acid reactive substances.


Localization (mononuclear cells) of coenzyme Q10 in blood associated with fibrositis
7) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875645 Disease Relevance 1.06 Pain Relevance 0.23
-tocopherol; BMCs: blood mononuclear cells; CoQ10: coenzyme Q10; FM: fibromyalgia; MPT: mitochondrial permeability transition; ROS: reactive oxygen species; TBARS: thiobarbituric acid reactive substances.


Localization (mononuclear cells) of CoQ10 in blood associated with fibrositis
8) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875645 Disease Relevance 1.06 Pain Relevance 0.23
Briefly, the frozen cells were homogenized with ice-cold water (1.3–1.5 ml/ sample) under an atmosphere of nitrogen gas, and then oxidized and reduced forms of CoQ9 and CoQ10 were extracted with a mixture of 2 volumes of ethanol and 5 volumes of n-hexane to 1 volume of homogenate, and further extracted two times.
Localization (forms) of CoQ10
9) Confidence 0.14 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872230 Disease Relevance 0.08 Pain Relevance 0
Measurement of CoQ9 and CoQ10
Localization (Measurement) of CoQ10
10) Confidence 0.13 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872230 Disease Relevance 0.16 Pain Relevance 0

General Comments

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