INT229912

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.57
Pain Relevance 3.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fyn) endosome (Fyn) mitochondrion (Fyn)
plasma membrane (Fyn)
Anatomy Link Frequency
tail 2
telencephalon 1
spinal cord 1
Fyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 136 100.00 Very High Very High Very High
Pain 73 98.76 Very High Very High Very High
Eae 44 98.36 Very High Very High Very High
Stimulus evoked pain 3 95.68 Very High Very High Very High
Spinal cord 173 95.36 Very High Very High Very High
central sensitization 39 92.84 High High
long-term potentiation 21 91.52 High High
nociceptor 11 89.64 High High
Hyperalgesia 145 87.64 High High
Peripheral nerve injury 1 83.32 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 92 99.72 Very High Very High Very High
Pain 122 98.76 Very High Very High Very High
Inflammatory Pain 31 98.36 Very High Very High Very High
Hypersensitivity 3 95.68 Very High Very High Very High
Hyperalgesia 219 87.64 High High
Nervous System Injury 14 83.32 Quite High
Nociception 70 76.56 Quite High
Injury 31 74.48 Quite High
Post Operative Pain 11 73.88 Quite High
INFLAMMATION 82 72.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among those tyrosines, Tyr-1472 appears to be the major Fyn-mediated phosphorylation site.
Phosphorylation (phosphorylation) of Fyn
1) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.80 Pain Relevance 1.08
NR2 is tyrosine phosphorylated at its C-terminal tails by Src-family tyrosine kinases, such as Src, Fyn [28,29].
Phosphorylation (phosphorylated) of Fyn in tails
2) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.63 Pain Relevance 1.13
Nakazawa et al. (2001) reported 25 tyrosine residues at the carboxyl tail of NR2B which could be phosphorylated by Fyn, including Tyr1252, Tyr1336, and Tyr1472 residues.
Phosphorylation (phosphorylated) of Fyn in tail
3) Confidence 0.35 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.08 Pain Relevance 0.27
Fyn proto-oncogene phosphorylates NMDA receptors in response to pain stimuli [19].
Phosphorylation (phosphorylates) of Fyn proto-oncogene associated with pain and nmda receptor
4) Confidence 0.30 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 0.76 Pain Relevance 0.76
In the mouse telencephalon, this residue was shown to be phosphorylated by a Src family member named Fyn (Nakazawa et al., 2001).
Phosphorylation (phosphorylated) of Fyn in telencephalon
5) Confidence 0.27 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0 Pain Relevance 0.09
Evidence exists for a role at least of Fyn and Src in NMDA receptor phosphorylation (Salter and Kalia, 2004), therefore we cannot exclude that a combination of at least these two Src family kinases is responsible for ephrinB2-mediated NR2B phosphorylation in our spinal cord plasticity model.
Phosphorylation (phosphorylation) of Fyn in spinal cord associated with nmda receptor and spinal cord
6) Confidence 0.27 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.22 Pain Relevance 0.32
We consequently investigated the state of phosphorylation of the Tyr418 residue of Src-family kinases with identical conserved regions (Src, Fyn and Yes) co-precipitated with NR2B.
Spec (investigated) Phosphorylation (phosphorylation) of Fyn
7) Confidence 0.12 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.08 Pain Relevance 0.13

General Comments

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