INT229914

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.03
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Egr1, Mapk3) nucleus (Egr1, Mapk3) nucleoplasm (Mapk3)
mitochondrion (Mapk3) Golgi apparatus (Mapk3) intracellular (Egr1)
Egr1 (Rattus norvegicus)
Mapk3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 4 100.00 Very High Very High Very High
Lasting pain 8 96.80 Very High Very High Very High
Glutamate 1 95.84 Very High Very High Very High
nMDA receptor 4 92.76 High High
Glutamate receptor 1 89.52 High High
Pain 39 88.88 High High
nociceptor 1 73.96 Quite High
Inflammation 38 71.64 Quite High
Spinal cord 15 70.56 Quite High
Neuropeptide 4 67.88 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 3 100.00 Very High Very High Very High
Pain 58 96.80 Very High Very High Very High
Nociception 2 81.32 Quite High
INFLAMMATION 42 71.64 Quite High
Hyperalgesia 27 50.00 Quite Low
Neurodegenerative Disease 5 46.00 Quite Low
Injury 5 5.00 Very Low Very Low Very Low
Frailty 3 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of MAPK cascade might be mediated by neurotensin receptor via Egr1, which is known to be upregulated in response to persistent inflammatory pain [29] and stimulates Erk1/2 phosphorylation [36].
Egr1 Positive_regulation (stimulates) of Phosphorylation (phosphorylation) of Erk1 associated with eae
1) Confidence 0.46 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 1.03 Pain Relevance 1.02

General Comments

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