INT229966

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.22
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (C9) plasma membrane (C9)
Anatomy Link Frequency
pore 1
C9 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 69 33.96 Quite Low
Inflammation 43 20.36 Low Low
alcohol 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
eye pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue 192 97.76 Very High Very High Very High
Age-related Macular Degeneration 130 96.12 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 10 87.44 High High
Infection 74 61.56 Quite High
INFLAMMATION 48 20.36 Low Low
Apoptosis 15 15.04 Low Low
Rupture 2 9.80 Low Low
Uveitis 110 5.00 Very Low Very Low Very Low
Dengue Hemorrhagic Fever 93 5.00 Very Low Very Low Very Low
Disease 54 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This complex can bind and stabilize C5a that forms the central effector function of the complement system around which proteins C5-C9 will bind and cooperatively lyse the cell.
C9 Binding (bind) of
1) Confidence 0.47 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.12 Pain Relevance 0
This complex can bind and stabilize C5a that forms the central effector function of the complement system around which proteins C5-C9 will bind and cooperatively lyse the cell.
C9 Binding (bind) of
2) Confidence 0.36 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.12 Pain Relevance 0
However, when patient samples were analyzed the found a strong correlation between NS1 concentration and C5b-C9 complex formation.


C9 Binding (formation) of
3) Confidence 0.35 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.54 Pain Relevance 0
The membrane-bound as well as recombinant-soluble (rs) CD59, bind to C9 and C8 and inhibit the polymerization of C9 which is prerequisite for MAC formation.
C9 Binding (polymerization) of
4) Confidence 0.09 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.72 Pain Relevance 0
MAC is a complex assembly of C5b to C9 components with multimers of C9 forming a pore in the cell membrane.
C9 Binding (multimers) of in pore
5) Confidence 0.09 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.71 Pain Relevance 0

General Comments

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