INT229968

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.87
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C1S) extracellular region (C1S)
Anatomy Link Frequency
plasma 1
Heart 1
C1S (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 9 83.32 Quite High
ischemia 1 41.88 Quite Low
cva 11 39.76 Quite Low
Inflammation 22 22.96 Low Low
abdominal pain 2 21.76 Low Low
withdrawal 1 18.96 Low Low
Bile 19 5.00 Very Low Very Low Very Low
bradykinin 13 5.00 Very Low Very Low Very Low
Bioavailability 8 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 258 100.00 Very High Very High Very High
Diabetes Mellitus 35 100.00 Very High Very High Very High
Atherosclerosis 17 100.00 Very High Very High Very High
Hereditary Angioedema 78 99.64 Very High Very High Very High
Coronary Artery Disease 113 98.88 Very High Very High Very High
Cardiovascular Disease 61 98.28 Very High Very High Very High
Metabolic Syndrome 12 98.20 Very High Very High Very High
Sudden Death 1 96.76 Very High Very High Very High
Pancreatitis 2 91.96 High High
Pressure And Volume Under Development 41 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, treatment of individuals with low HDL-C is only considered for high risk patients with metabolic syndrome, and only after LDL-C has been treated.
C is Binding (individuals) of associated with metabolic syndrome and disorder of lipid metabolism
1) Confidence 0.36 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 0.83 Pain Relevance 0
In diabetic patients, although elevated LDL-C is not the major lipid abnormality, both the American Heart Association (AHA) and the American Diabetes Association (ADA) recognize lowering LDL-C as the primary measure for CVD prevention.
C is Binding (recognize) of in Heart associated with cardiovascular disease and diabetes mellitus
2) Confidence 0.36 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 1.34 Pain Relevance 0
Elevated LDL-C is an important contributory factor to development of atherosclerosis, and as such is recognized as a major risk factor for CHD.
C is Binding (recognized) of associated with coronary artery disease and atherosclerosis
3) Confidence 0.35 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663459 Disease Relevance 1.03 Pain Relevance 0
Attacks of hereditary angioedema result from contact, complement, and fibrinolytic plasma cascade activation, where C1 esterase inhibitor irreversibly binds substrates.
C1 esterase Binding (binds) of in plasma associated with hereditary angioedema
4) Confidence 0.34 Published 2010 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2965712 Disease Relevance 1.18 Pain Relevance 0.08
Patients with hereditary angioedema cannot replenish C1 esterase inhibitor levels on pace with its binding.
C1 esterase Binding (binding) of associated with hereditary angioedema
5) Confidence 0.26 Published 2010 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2965712 Disease Relevance 1.18 Pain Relevance 0.08
C1-INH functional assays may use chromogenic or C1s binding ELISA assays.
C1s Binding (binding) of
6) Confidence 0.14 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921362 Disease Relevance 0.24 Pain Relevance 0
It also prevents spontaneous activation of C1 and binding to the zymogen forms of C1r and C1s [24].
C1s Binding (binding) of
7) Confidence 0.11 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0 Pain Relevance 0

General Comments

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