INT229983

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CFH, Crp) extracellular region (CFH)
CFH (Homo sapiens)
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 24 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
cva 9 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
tissue acidosis 1 5.00 Very Low Very Low Very Low
eye pain 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 3 93.60 High High
Age-related Macular Degeneration 73 88.12 High High
Ocular Toxicity (including Many Sub-types) 5 70.88 Quite High
Paroxysmal Nocturnal Hemoglobinuria 27 60.80 Quite High
Blindness 3 55.40 Quite High
Sepsis 8 51.16 Quite High
Coronary Artery Disease 16 48.80 Quite Low
Paralysis 2 42.60 Quite Low
Disease 26 27.64 Quite Low
Glomerulonephritis 23 21.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies using factor H purified from serum and recombinant factor H showed decreased binding of the 402His variant of factor H to CRP and heparin as compared to the wild-type 402Tyr variant (Clark et al 2006; Laine et al 2007).
factor H Binding (binding) of CRP
1) Confidence 0.14 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.80 Pain Relevance 0
Binding of CFH to CRP and GAG plays an important role in the regulation of the alternative pathway.
CFH Binding (Binding) of CRP
2) Confidence 0.09 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.68 Pain Relevance 0

General Comments

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