INT230

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Context Info
Confidence 0.68
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 11.78
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
Liver 1
erythrocyte 1
thrombocyte 1
upper 1
GGTLC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 99.84 Very High Very High Very High
Glutamate 2 99.52 Very High Very High Very High
withdrawal 5 99.16 Very High Very High Very High
headache 9 97.28 Very High Very High Very High
abdominal pain 9 95.96 Very High Very High Very High
pruritus 1 95.44 Very High Very High Very High
Pain 9 92.76 High High
Bile 31 89.04 High High
fibrosis 1 86.80 High High
Paracetamol 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 9 100.00 Very High Very High Very High
Choledocholithiasis 7 100.00 Very High Very High Very High
Neutropenia 1 99.90 Very High Very High Very High
Pancreatitis 10 99.84 Very High Very High Very High
Hepatomegaly 4 99.76 Very High Very High Very High
Gallstones 2 99.70 Very High Very High Very High
Toxicity 36 99.66 Very High Very High Very High
Hyperbilirubinemia 1 98.60 Very High Very High Very High
Metastasis 11 98.44 Very High Very High Very High
Cancer 73 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Symptoms disappeared three days after withdrawal of the drug, but hepatomegaly and a mild increase in serum gamma-glutamyl-transpeptidase persisted more than eighteen months.
Positive_regulation (increase) of gamma-glutamyl-transpeptidase associated with hepatomegaly and withdrawal
1) Confidence 0.68 Published 1986 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 3732735 Disease Relevance 1.16 Pain Relevance 0.16
INVESTIGATIONS: Alkaline phosphatase and gamma-glutamyl transpeptidase activities as well erythrocyte sedimentation rate were increased.
Positive_regulation (increased) of gamma-glutamyl transpeptidase in erythrocyte
2) Confidence 0.35 Published 1997 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 9378054 Disease Relevance 0.10 Pain Relevance 0
During infusion of caerulein, the output of gamma-glutamyl transpeptidase and biliary alkaline phosphatase is significantly more increased in chronic pancreatitis patients than in normal subjects.
Positive_regulation (increased) of gamma-glutamyl transpeptidase associated with chronic pancreatitis
3) Confidence 0.34 Published 1977 Journal Digestion Section Abstract Doc Link 19331 Disease Relevance 0.17 Pain Relevance 0.17
An increased risk of bleeding was also described in the pediatric and adolescent study.78 When considering laboratory abnormalities, elevations in gamma-glutamyl transpeptidase and alanine transaminase led to discontinuation of tipranavir in four patients.78
Positive_regulation (elevations) of gamma-glutamyl transpeptidase associated with congenital anomalies and hemorrhage
4) Confidence 0.15 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952481 Disease Relevance 0.96 Pain Relevance 0.09
The effects of age, nature (single or multiple) and stated size of overdose, hepatic enzyme induction (gamma-glutamyl transpeptidase, GGT), degree of liver injury (aspartate aminotransferase, prothrombin time), blood pressure and renal injury were assessed.
Positive_regulation (induction) of gamma-glutamyl transpeptidase in blood
5) Confidence 0.10 Published 2009 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 18958458 Disease Relevance 0.08 Pain Relevance 0
Biochemically a slight increase of transaminases, alkaline phosphatase and gammaglutamyl transpeptidase were present; alpha-fetoprotein, carcinoembryogenic antigen and carbohydrate 19-9 antigen serum levels were normal.
Positive_regulation (increase) of transpeptidase
6) Confidence 0.08 Published 2004 Journal World J. Gastroenterol. Section Abstract Doc Link 15285043 Disease Relevance 1.18 Pain Relevance 0.09
Grade 3 elevation of gamma-glutamyl transpeptidase was observed in one patient at 25 mg/kg and was considered to be dose limiting.
Positive_regulation (elevation) of gamma-glutamyl transpeptidase
7) Confidence 0.07 Published 2009 Journal Japanese Journal of Clinical Oncology Section Abstract Doc Link PMC2661001 Disease Relevance 0.92 Pain Relevance 0
Objective toxicity included transient neutropenia and elevation of hepatic enzymes, particularly gamma-glutamyl transpeptidase.
Positive_regulation (elevation) of gamma-glutamyl transpeptidase associated with neutropenia and toxicity
8) Confidence 0.06 Published 1986 Journal J. Interferon Res. Section Abstract Doc Link 2871116 Disease Relevance 1.02 Pain Relevance 0.10
Liver function tests are consistent with cholestasis and reveal an elevation of serum alkaline phosphatase and gamma-glutamyl transpeptidase with or without elevation of aminotransferase levels.
Positive_regulation (elevation) of gamma-glutamyl transpeptidase in Liver associated with gallstones
9) Confidence 0.05 Published 2001 Journal Semin. Gastrointest. Dis. Section Abstract Doc Link 11352123 Disease Relevance 1.10 Pain Relevance 0.14
High serum gamma glutamyl transpeptidase and alkaline phosphatase were the most frequent biochemical abnormalities in patients with symptomatic choledocholithiasis: they were increased in 94 and 91% of cases, respectively.
Positive_regulation (increased) of serum gamma glutamyl transpeptidase associated with choledocholithiasis and congenital anomalies
10) Confidence 0.04 Published 1986 Journal Dig. Dis. Sci. Section Abstract Doc Link 2870885 Disease Relevance 0.84 Pain Relevance 0.13
In four patients, grade III or IV toxicity was observed as gamma-glutamyl transpeptidase elevation.
Positive_regulation (elevation) of gamma-glutamyl transpeptidase associated with toxicity
11) Confidence 0.04 Published 2003 Journal Am. J. Clin. Oncol. Section Abstract Doc Link 12714888 Disease Relevance 1.17 Pain Relevance 0.10
Glutamate-oxalate transaminase, glutamate-pyruvate transaminase, gamma-glutamyl transpeptidase, alpha-amylase, and lipase remained mildly elevated and the thrombocyte count and the glomerular filtration rate mildly declined before, during, and after telbivudine treatment (table 1).
Positive_regulation (elevated) of gamma-glutamyl transpeptidase in thrombocyte associated with glutamate
12) Confidence 0.02 Published 2010 Journal Virol J Section Body Doc Link PMC2998482 Disease Relevance 0.69 Pain Relevance 0.22
Except for one instance of a grade 4 event (elevated gamma-glutamyltranspeptidase: GGT) in the 700 ?
Positive_regulation (elevated) of gamma-glutamyltranspeptidase
13) Confidence 0.01 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761172 Disease Relevance 1.57 Pain Relevance 0.22
Hyperbilirubinemia (total bilirubin > 1.2 mg/dL) was evident in 30 patients (76.9%) and elevated levels of Alkaline Phosphatase and Gamma Glutamyl Transpeptidase (ALP > 230 IU/L, GGT > 48 IU/L) were found in all cases except one (97.4%) who was diagnosed incidentally during the upper gastrointestinal endoscopy.


Positive_regulation (elevated) of Gamma Glutamyl Transpeptidase in upper associated with hyperbilirubinemia
14) Confidence 0.01 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1933541 Disease Relevance 0.81 Pain Relevance 0.12

General Comments

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