INT230002

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.59
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CAMK4) nucleoplasm (CAMK4) signal transduction (CAMK4)
nucleus (CAMK4) cytoplasm (CAMK4)
Anatomy Link Frequency
liver 2
CAMK4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 33 86.44 High High
Inflammation 50 84.44 Quite High
Dismenorea 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 4 100.00 Very High Very High Very High
Diabetes Mellitus 22 99.22 Very High Very High Very High
Hyperinsulinism 1 98.56 Very High Very High Very High
Stress 6 97.40 Very High Very High Very High
Cancer 48 94.08 High High
Neuroblastoma 50 91.36 High High
Shock 1 88.84 High High
INFLAMMATION 53 84.44 Quite High
Premature Birth 35 78.08 Quite High
Obesity 43 76.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HSP47 encodes a collagen-specific molecular chaperone and is essential for the production and maturation of collagens I and IV (Sauk et al. 2005).
Gene_expression (production) of and IV
1) Confidence 0.09 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 0.99 Pain Relevance 0
In fasted young animals there is a dramatic increase in liver mRNA synthesis and serum levels of APO A-I and A-IV in response to glucocorticoids and insulin increased by fasting stress [22].
Gene_expression (levels) of A-IV in liver associated with stress and hyperinsulinism
2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2315798 Disease Relevance 0.86 Pain Relevance 0.08
Analysis of 42 genes associated with diabetes by RT q-PCR showed that in the liver, expression of Gk, Glut-2, apolipoprotein A-IV (ApoA-IV), PPAR?
Gene_expression (expression) of A-IV in liver associated with diabetes mellitus and disorder of lipid metabolism
3) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.73 Pain Relevance 0.14

General Comments

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