INT230061

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Context Info
Confidence 0.66
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.42
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Accs)
Anatomy Link Frequency
amnion 1
Accs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 84 100.00 Very High Very High Very High
metalloproteinase 21 85.68 High High
Lasting pain 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 210 99.24 Very High Very High Very High
Wound Healing 57 97.16 Very High Very High Very High
Hernia 99 68.16 Quite High
Burns 6 5.00 Very Low Very Low Very Low
Superinfection 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Bites And Stings 3 5.00 Very Low Very Low Very Low
Cicatrix 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AMP cells were grown to confluency, and using proprietary techniques, the supernatant was harvested.8 This secreted product, labeled ACCS, was then used in both the acute wound model and the chronic wound model.
Localization (secreted) of ACCS associated with injury
1) Confidence 0.66 Published 2008 Journal Eplasty Section Body Doc Link PMC2323202 Disease Relevance 0.50 Pain Relevance 0.36
From the previous report on AMP cells in the acute wound model and these observations of ACCS treatment in both acute and chronic wounds, it appears that AMP cells and their secreted products in ACCS can form a novel platform technology for further investigation in the wound healing arena.


Localization (secreted) of ACCS associated with wound healing and injury
2) Confidence 0.50 Published 2008 Journal Eplasty Section Body Doc Link PMC2323202 Disease Relevance 0.59 Pain Relevance 0.23
Amnion-derived multipotent progenitor (AMP) cells were recently reported to increase the rate of gain of incisional breaking strength and decrease the incidence and severity of acute wound failure.7 It was postulated that one of the possible mechanisms for the improvement of acute wound healing in these experiments was that the AMP cells could be making the necessary cytokine cocktail at the proper time and dose to affect a trajectory shift.7 The secreted cytokines from AMP cells, amnion-derived cellular cytokine solution (ACCS), have been studied using qualitative antibody arrays, enzyme-linked immunosorbent assays, multiplex, and mass spectroscopy.
Localization (secreted) of ACCS in amnion associated with wound healing, injury and cytokine
3) Confidence 0.50 Published 2008 Journal Eplasty Section Body Doc Link PMC2323202 Disease Relevance 0.32 Pain Relevance 0.36

General Comments

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