INT230065

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DOA) unfolded protein binding (TOR1A) protein folding (TOR1A)
endoplasmic reticulum (TOR1A) plasma membrane (HLA-DOA) nucleus (TOR1A)
Anatomy Link Frequency
leukocyte 1
T cell 1
TOR1A (Homo sapiens)
HLA-DOA (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 4 80.64 Quite High
peptic ulcer disease 2 54.64 Quite High
Inflammation 44 28.04 Quite Low
cytokine 20 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Infliximab 4 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 132 98.92 Very High Very High Very High
Celiac Disease 116 98.88 Very High Very High Very High
Genetic Predisposition To Disease 6 98.48 Very High Very High Very High
Infection 10 81.16 Quite High
Communicable Diseases 6 73.40 Quite High
T-cell Lymphoma 12 66.32 Quite High
Stomach Cancer 4 56.12 Quite High
Ulcers 6 54.32 Quite High
Lymphatic System Cancer 4 49.60 Quite Low
Disease Susceptibility 2 44.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human leukocyte antigen (HLA) DQ2 is associated with over 90% of diagnosed celiac sprue patients, while HLA DQ8 is present in virtually all other cases [34].
DQ2 Binding (associated) of HLA in leukocyte associated with celiac disease
1) Confidence 0.00 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.96 Pain Relevance 0.05
These include in vitro models for gluten peptide gastrointestinal digestion [23,24,159,160], transepithelial transport [89], TG2-mediated deamidation [126], HLA-DQ2 binding and presentation [134,135,161], T cell activation [136,162], and enactment of innate immune responses through direct toxic effects [144,145].
DQ2 Binding (binding) of HLA in T cell
2) Confidence 0.00 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.69 Pain Relevance 0.04

General Comments

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