INT230086

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 6.06
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
chondrocyte 2
NK cells 2
stem cells 2
T cells 2
IFN1@ (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 158 100.00 Very High Very High Very High
Inflammation 89 95.88 Very High Very High Very High
psoriasis 68 94.20 High High
rheumatoid arthritis 39 89.80 High High
Arthritis 21 76.56 Quite High
Osteoarthritis 33 5.00 Very Low Very Low Very Low
COX2 30 5.00 Very Low Very Low Very Low
Infliximab 18 5.00 Very Low Very Low Very Low
chemokine 18 5.00 Very Low Very Low Very Low
Etanercept 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 76 99.48 Very High Very High Very High
Toxicity 115 98.08 Very High Very High Very High
Hypersensitivity Pneumonitis 70 96.40 Very High Very High Very High
INFLAMMATION 93 95.88 Very High Very High Very High
Targeted Disruption 36 95.68 Very High Very High Very High
Cancer 454 93.88 High High
Rheumatoid Arthritis 39 89.80 High High
Disease 140 87.28 High High
Autoimmune Disease 5 82.00 Quite High
Squamous Cell Carcinoma 24 80.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, MSCs and their chondrocyte progeny alike inhibited the secretion of proinflammatory cytokines IFN-?
Negative_regulation (inhibited) of Localization (secretion) of IFN in chondrocyte associated with cytokine
1) Confidence 0.57 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 1.04 Pain Relevance 0.40
However, TLR4pre inhibited the releases of IL-10 and IFN-?
Negative_regulation (inhibited) of Localization (releases) of IFN
2) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.14 Pain Relevance 0.08
It inhibits the secretion of IFN-?
Negative_regulation (inhibits) of Localization (secretion) of IFN
3) Confidence 0.57 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.81 Pain Relevance 0.48
In ex vivo biopsy culture experiments, IL-15 is known to be induced by p31–43, and it also drives secretion of IFN-?
Negative_regulation (drives) of Localization (secretion) of IFN
4) Confidence 0.41 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.56 Pain Relevance 0.20
dose reduction, it was reported in only 44% and 41% of patients in the bevacizumab and placebo groups, respectively, in the 6 weeks prior to IFN-?
Negative_regulation (reduction) of Localization (reported) of IFN
5) Confidence 0.41 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 0.49 Pain Relevance 0
Of those patients who received reduced doses of IFN-?
Negative_regulation (reduced) of Localization (doses) of IFN
6) Confidence 0.41 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 0.41 Pain Relevance 0
Of those patients who received reduced doses of IFN-?
Negative_regulation (received) of Localization (doses) of IFN
7) Confidence 0.41 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 0.42 Pain Relevance 0
and IL-6 secretion, we could demonstrate a direct correlation between decreased IL-6 and increased IFN-?
Negative_regulation (decreased) of Localization (correlation) of IFN
8) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.64 Pain Relevance 0.03
Lysis of hMSCs by untreated and IL-2 treated NK cells is inhibited by monocytes, however, the addition of monocytes induced significant secretion of IFN-?
Negative_regulation (inhibited) of Localization (secretion) of IFN in NK cells
9) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.05 Pain Relevance 0
Indeed, stem cells triggered significant secretion of IFN-?
Negative_regulation (triggered) of Localization (secretion) of IFN in stem cells
10) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.15 Pain Relevance 0
produced by CD4+ T cells might compensate reduced amount of IFN-?
Negative_regulation (reduced) of Localization (amount) of IFN in T cells
11) Confidence 0.41 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.85 Pain Relevance 0.06
An exploratory analysis50 demonstrated patients receiving a reduced dose of IFN-?
Negative_regulation (reduced) of Localization (dose) of IFN
12) Confidence 0.41 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 0.49 Pain Relevance 0

General Comments

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