INT230087

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.84
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (TOR1A) protein folding (TOR1A) endoplasmic reticulum (TOR1A)
nucleus (TOR1A) cytoplasm (TOR1A)
Anatomy Link Frequency
T cell 2
leukocyte 1
TOR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 11 99.88 Very High Very High Very High
tolerance 10 94.08 High High
rheumatoid arthritis 63 89.80 High High
cytokine 78 87.80 High High
Inflammation 125 78.80 Quite High
Inflammatory response 24 68.08 Quite High
peptic ulcer disease 5 54.44 Quite High
Infliximab 28 17.20 Low Low
Potency 5 14.32 Low Low
methotrexate 39 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 347 99.76 Very High Very High Very High
Celiac Disease 290 98.88 Very High Very High Very High
Genetic Predisposition To Disease 16 98.28 Very High Very High Very High
Autoimmune Disease 3 98.00 Very High Very High Very High
Rheumatoid Arthritis 64 89.80 High High
Immunization 5 89.20 High High
Infection 27 81.00 Quite High
INFLAMMATION 143 78.80 Quite High
Communicable Diseases 15 73.24 Quite High
T-cell Lymphoma 30 66.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The uncommon A allele is strongly associated with the HLA-A1-B8-DR3-DQ2 haplotype [18], and is also associated with both autoimmune diseases and the high TNF producer phenotype [19].
DQ2 Binding (associated) of associated with autoimmune disease
1) Confidence 0.35 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 0.49 Pain Relevance 0.23
To block the immune response in situ, peptidomimetic inhibitors that bind HLA DQ2 but are not recognized by gluten-specific T cell receptors can be designed using the crystal structure of HLA DQ2 bound to a gluten peptide as a guide [135,201].
DQ2 Neg (not) Binding (bind) of in T cell
2) Confidence 0.08 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.16 Pain Relevance 0.08
Due to the remarkable concordance between the role that TG2 plays in increasing these immunogenic peptides' affinity for DQ2, the identity of TG2 as the target of the autoantibody response, and the strong genetic association of DQ2 with disease, research into celiac pathogenesis has largely focused on the adaptive branch of the immune response.
DQ2 Binding (association) of associated with disease
3) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.35 Pain Relevance 0.14
Human leukocyte antigen (HLA) DQ2 is associated with over 90% of diagnosed celiac sprue patients, while HLA DQ8 is present in virtually all other cases [34].
DQ2 Binding (associated) of in leukocyte associated with celiac disease
4) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.96 Pain Relevance 0.05
These include in vitro models for gluten peptide gastrointestinal digestion [23,24,159,160], transepithelial transport [89], TG2-mediated deamidation [126], HLA-DQ2 binding and presentation [134,135,161], T cell activation [136,162], and enactment of innate immune responses through direct toxic effects [144,145].
DQ2 Binding (binding) of in T cell
5) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.69 Pain Relevance 0.04
By building these inhibitors from a gluten peptide scaffold, it is hoped that such DQ2 blockers will possess similar proteolytic resistance, bioavailability, and affinity for DQ2 as immunotoxic gluten peptides.
DQ2 Binding (affinity) of associated with bioavailability
6) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.20 Pain Relevance 0.12

General Comments

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