INT230092

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (TOR1A) protein folding (TOR1A) endoplasmic reticulum (TOR1A)
nucleus (TOR1A) cytoplasm (TOR1A)
TOR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 93.56 High High
Inflammation 22 70.24 Quite High
Inflammatory response 4 30.88 Quite Low
Potency 1 20.08 Low Low
Bioavailability 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
peptic ulcer disease 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 66 95.48 Very High Very High Very High
INFLAMMATION 25 70.24 Quite High
Communicable Diseases 3 35.80 Quite Low
Celiac Disease 58 33.52 Quite Low
Stress 5 7.92 Low Low
T-cell Lymphoma 6 5.00 Very Low Very Low Very Low
Enteropathy 5 5.00 Very Low Very Low Very Low
Infection 5 5.00 Very Low Very Low Very Low
Ulcers 3 5.00 Very Low Very Low Very Low
Crohn's Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Due to the remarkable concordance between the role that TG2 plays in increasing these immunogenic peptides' affinity for DQ2, the identity of TG2 as the target of the autoantibody response, and the strong genetic association of DQ2 with disease, research into celiac pathogenesis has largely focused on the adaptive branch of the immune response.
Positive_regulation (increasing) of DQ2 associated with disease
1) Confidence 0.09 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.35 Pain Relevance 0.17

General Comments

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