INT230097

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.93
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (TOR1A) protein folding (TOR1A) endoplasmic reticulum (TOR1A)
nucleus (TOR1A) cytoplasm (TOR1A)
Anatomy Link Frequency
leukocyte 1
lamina 1
TOR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 66 88.24 High High
peptic ulcer disease 3 51.32 Quite High
cytokine 30 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Bioavailability 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Infliximab 6 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Celiac Disease 174 99.58 Very High Very High Very High
Targeted Disruption 9 98.10 Very High Very High Very High
Disease 198 95.60 Very High Very High Very High
Genetic Predisposition To Disease 9 95.16 Very High Very High Very High
Disease Progression 6 92.56 High High
INFLAMMATION 75 88.24 High High
Bullous Skin Disease 3 80.32 Quite High
Enteropathy 15 68.16 Quite High
Communicable Diseases 9 56.20 Quite High
Stomach Cancer 6 52.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human leukocyte antigen (HLA) DQ2 is associated with over 90% of diagnosed celiac sprue patients, while HLA DQ8 is present in virtually all other cases [34].
Gene_expression (present) of DQ8 in leukocyte associated with celiac disease
1) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.95 Pain Relevance 0.05
Finally, several transgenic mouse models have been engineered to mimic celiac sprue, most notably the NOD Ab° DQ8+ mouse, which expresses human DQ8 in an endogenous MHC class II-deficient (Ab°), autoimmune-prone (NOD) background [173].
Gene_expression (expresses) of DQ8 associated with targeted disruption and celiac disease
2) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.79 Pain Relevance 0
Likewise, the antigen-presenting cells that present DQ2-bound gluten to CD4+ T cells in the lamina propria remain to be definitively identified.
Gene_expression (present) of DQ2 in lamina
3) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 1.18 Pain Relevance 0.12

General Comments

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