INT230099

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 2.77
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TGM2) plasma membrane (TGM2) transferase activity, transferring acyl groups (TGM2)
cytoplasm (TGM2)
Anatomy Link Frequency
T cell 3
TGM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 7 78.92 Quite High
Infliximab 14 68.64 Quite High
cytokine 70 63.92 Quite High
tolerance 14 39.44 Quite Low
Potency 7 19.12 Low Low
Inflammation 154 5.00 Very Low Very Low Very Low
Inflammatory response 28 5.00 Very Low Very Low Very Low
Bioavailability 14 5.00 Very Low Very Low Very Low
peptic ulcer disease 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Celiac Disease 406 98.36 Very High Very High Very High
Disease 462 96.08 Very High Very High Very High
Diabetes Mellitus 21 87.60 High High
Crohn's Disease 21 72.24 Quite High
Immunization 7 49.44 Quite Low
INFLAMMATION 175 5.00 Very Low Very Low Very Low
T-cell Lymphoma 42 5.00 Very Low Very Low Very Low
Enteropathy 35 5.00 Very Low Very Low Very Low
Infection 35 5.00 Very Low Very Low Very Low
Stress 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A major caveat to approaches focusing on preventing gluten deamidation is that some non-deamidated gluten peptides can induce T cell responses from celiac patient biopsies, suggesting that TG2 inhibition may not by itself protect celiac patients from ingested gluten [60,137].


Negative_regulation (inhibition) of TG2 in T cell
1) Confidence 0.31 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.09 Pain Relevance 0
As an alternative to inhibiting TG2, it may be possible to block deamidation sites in gluten peptides in vivo, by dual oral administration of a microbial transglutaminase and a suitable amine blocker.
Negative_regulation (inhibiting) of TG2
2) Confidence 0.31 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.34 Pain Relevance 0.03
The most obvious means of intervening at this stage of gluten pathogenicity is to inhibit TG2 activity directly, and indeed, inhibition of TG2 in cultured celiac patient–derived intestinal biopsies reduces gluten-specific T cell activation [152,190].
Negative_regulation (inhibit) of TG2 in T cell
3) Confidence 0.31 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.40 Pain Relevance 0.11
Pharmacological inhibitors of TG2 activity have been reviewed [191].
Negative_regulation (inhibitors) of TG2
4) Confidence 0.31 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.39 Pain Relevance 0.09
Upon treatment with a gluten-free diet, anti-TG2 autoantibody levels decline.
Negative_regulation (decline) of TG2
5) Confidence 0.27 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.77 Pain Relevance 0
Recent studies have highlighted the potential for mechanism-based TG2 inhibitors to be of particular benefit in treating celiac sprue [192–194].
Negative_regulation (inhibitors) of TG2 associated with celiac disease
6) Confidence 0.27 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.38 Pain Relevance 0.09
The most obvious means of intervening at this stage of gluten pathogenicity is to inhibit TG2 activity directly, and indeed, inhibition of TG2 in cultured celiac patient–derived intestinal biopsies reduces gluten-specific T cell activation [152,190].
Negative_regulation (inhibition) of TG2 in T cell
7) Confidence 0.27 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.40 Pain Relevance 0.10

General Comments

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