INT23010

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Context Info
Confidence 0.58
First Reported 1989
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 24.18
Pain Relevance 5.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYP19A1) small molecule metabolic process (CYP19A1) endoplasmic reticulum (CYP19A1)
cytoplasm (CYP19A1)
Anatomy Link Frequency
stroma 3
fat 2
epithelium 2
myometrium 1
liver 1
CYP19A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 12 100.00 Very High Very High Very High
endometriosis 207 99.96 Very High Very High Very High
rheumatoid arthritis 187 99.90 Very High Very High Very High
cva 51 99.80 Very High Very High Very High
cINOD 97 99.76 Very High Very High Very High
antagonist 139 99.30 Very High Very High Very High
Osteoarthritis 98 99.22 Very High Very High Very High
Inflammation 116 99.10 Very High Very High Very High
cytokine 62 98.00 Very High Very High Very High
ischemia 6 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dysmenorrhea 6 100.00 Very High Very High Very High
Endometriosis (extended) 75 99.96 Very High Very High Very High
Rheumatoid Arthritis 210 99.90 Very High Very High Very High
Breast Cancer 269 99.84 Very High Very High Very High
Hemorrhage 56 99.80 Very High Very High Very High
Injury 63 99.58 Very High Very High Very High
INFLAMMATION 157 99.52 Very High Very High Very High
Breast Disease 4 99.28 Very High Very High Very High
Frailty 108 99.22 Very High Very High Very High
Uterine Fibroids 72 99.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of an increase in total content of unsaturated fatty acids in microsomal lipids induced by phenobarbital, alterations of parameters of the fluorescent probe 1,8-ANS-binding with membranes as well as restrictions in induction of liver microsomal monooxygenase enzymatic system were detected during postischemic period after total liver tissue ischemia.
Positive_regulation (induction) of microsomal monooxygenase in liver associated with ischemia
1) Confidence 0.58 Published 1990 Journal Vopr. Med. Khim. Section Abstract Doc Link 2363249 Disease Relevance 0.10 Pain Relevance 0.21
Aromatase activity in adenomyosis was blocked by danazol, but stimulated by progesterone and MPA.
Positive_regulation (stimulated) of Aromatase associated with dismenorea
2) Confidence 0.47 Published 1989 Journal Acta Endocrinol. Section Abstract Doc Link 2528261 Disease Relevance 0.68 Pain Relevance 0.52
Recently, an important role for the leptin, the secretory product of adipocytes, in reproductive medicine has emerged and it is interesting to discuss in brief a possible link between leptin, induction of ovulation and aromatase inhibitors.
Spec (possible) Positive_regulation (induction) of aromatase in adipocytes associated with obesity
3) Confidence 0.39 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.35 Pain Relevance 0.08
This in addition to the absence of accumulation of the aromatase inhibitors of any of their metabolites would make them safe for the ovarian stimulation.
Positive_regulation (accumulation) of aromatase
4) Confidence 0.39 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0
In addition the use of aromatase inhibitors to improve the outcome of treatment after assisted reproduction as discussed earlier in this review is an exciting area of application.



1.3 Use of aromatase inhibitors to improve treatment outcome after ovarian stimulation and assisted reproduction

Positive_regulation (use) of aromatase
5) Confidence 0.39 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.61 Pain Relevance 0.05
MCF-7aro cells deprived of hormones showed 91.3 ± 2.1% of cells in G0/G1 phase, whereas in testosterone-induced growth of MCF-7aro cells (control cells), the percentage of cells arrested in G0/G1 phase was only 42.4 ± 2.3%, which indicates that aromatase present in MCF-7aro is converting testosterone into estradiol, inducing in that way cell proliferation.
Positive_regulation (inducing) of aromatase
6) Confidence 0.35 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2515307 Disease Relevance 0 Pain Relevance 0
In this model, increases in body fat lead to increases in aromatase levels, in addition to insulin resistance, adverse lipid profiles and increased leptin levels.
Positive_regulation (increases) of aromatase in fat associated with insulin resistance
7) Confidence 0.33 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 1.11 Pain Relevance 0
Increased action of aromatase in metabolizing testosterone to estrogen, reduces testosterone levels which induces further accumulation of visceral fat.
Positive_regulation (Increased) of aromatase in fat
8) Confidence 0.33 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 1.19 Pain Relevance 0
Furthermore, androgens can also increase aromatase gene expression [24].
Positive_regulation (increase) of aromatase gene
9) Confidence 0.33 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.57 Pain Relevance 0.29
Thus, it comes as little surprise that breast aromatase activity is increased in proliferative breast disease and many cases of breast cancer (2).
Positive_regulation (increased) of aromatase associated with breast disease and reprotox - general 1
10) Confidence 0.32 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 1.21 Pain Relevance 0.28
This underlines that inflammation in OA, apparently similar to that in RA, up-regulates aromatase activity leading to elevated levels of estrogens in synovial tissue.
Positive_regulation (regulates) of aromatase associated with inflammation, rheumatoid arthritis and osteoarthritis
11) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 1.56 Pain Relevance 0.63
Aromatase transcript expression and enzyme activity in breast tumor tissue is greater than that in the normal breast tissue, and prostaglandins can increase CYP19 expression and aromatase activity in breast cancer cells.
Positive_regulation (increase) of aromatase associated with breast cancer
12) Confidence 0.17 Published 2006 Journal Minerva Endocrinol. Section Abstract Doc Link 16498361 Disease Relevance 0.55 Pain Relevance 0.20
Moreover, these studies also suggest that mammary tumors are associated with high prostaglandin levels and induction of aromatase, a cytochrome P450 enzyme that catalyses estrogen production.
Positive_regulation (induction) of aromatase associated with cancer
13) Confidence 0.17 Published 2004 Journal Semin. Oncol. Section Abstract Doc Link 15179621 Disease Relevance 1.07 Pain Relevance 0.08
Aromatase transcript expression and activity in breast tumor tissue is greater than that in the normal breast tissue, and prostaglandins can increase CYP19 expression and aromatase activity in breast cancer cells.
Positive_regulation (increase) of aromatase associated with breast cancer
14) Confidence 0.16 Published 2006 Journal Anti-cancer agents in medicinal chemistry Section Abstract Doc Link 16712450 Disease Relevance 0.95 Pain Relevance 0.13
Increased aromatase activity promotes the growth of ER-positive breast cells, and this is of particular relevance to postmenopausal breast cancer, in which systemic oestrogens are low.
Positive_regulation (Increased) of aromatase associated with breast cancer
15) Confidence 0.15 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064113 Disease Relevance 1.07 Pain Relevance 0.32
Vitamin D3 is an important regulator of aromatase activity and physiological concentrations of vitamin D3 are necessary for maintenance of aromatase activity in osteoblasts [59].
Positive_regulation (maintenance) of aromatase in osteoblasts
16) Confidence 0.12 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1586194 Disease Relevance 0.19 Pain Relevance 0.03
An increase in the activity of aromatase induced locally could explain the drop in androgen levels and the increase in estrogens observed in patients with RA [38].
Positive_regulation (increase) of aromatase associated with rheumatoid arthritis
17) Confidence 0.10 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64847 Disease Relevance 1.20 Pain Relevance 0.18
In breast cancer PGs, particularly PGE2, have an organ-site-specific effect of increasing the levels of aromatase, thereby increasing estrogen and progesterone synthesis [10-12].
Positive_regulation (increasing) of aromatase associated with breast cancer
18) Confidence 0.10 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797023 Disease Relevance 1.12 Pain Relevance 0.32
COX-2 positive cells show increased aromatase activity due to the release of prostaglandins, increasing aromatase in surrounding stroma and epithelium, leading to synthesis of oestrogens in the microenvironment around COX-2 over-expressing cells [6].
Positive_regulation (increased) of aromatase in epithelium
19) Confidence 0.10 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064113 Disease Relevance 1.06 Pain Relevance 0.24
COX-2 positive cells show increased aromatase activity due to the release of prostaglandins, increasing aromatase in surrounding stroma and epithelium, leading to synthesis of oestrogens in the microenvironment around COX-2 over-expressing cells [6].
Positive_regulation (increasing) of aromatase in epithelium
20) Confidence 0.10 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064113 Disease Relevance 1.11 Pain Relevance 0.32

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