INT230117

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.44
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (KRT8) structural molecule activity (KRT8) nucleus (KRT8)
cytoskeleton organization (KRT8) cytoplasm (KRT8)
Anatomy Link Frequency
filaments 2
hepatocytes 1
lumen 1
epithelial cells 1
KRT8 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 44 98.32 Very High Very High Very High
Inflammation 26 5.00 Very Low Very Low Very Low
medulla 21 5.00 Very Low Very Low Very Low
backache 8 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 60 97.72 Very High Very High Very High
Cancer 289 95.36 Very High Very High Very High
Disease 44 92.76 High High
Lymphatic System Cancer 1 91.32 High High
Targeted Disruption 57 90.96 High High
Apoptosis 41 74.44 Quite High
Necrosis 8 71.56 Quite High
Death 3 69.68 Quite High
Stomach Cancer 1 66.68 Quite High
Lung Cancer 18 62.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KRT8 belongs to the intermediate filament family and associates with keratin 18 to form a heterotetramer of two type i and two type ii keratins.
KRT8 Binding (associates) of in filament
1) Confidence 0.31 Published 2007 Journal Bioinform Biol Insights Section Body Doc Link PMC2323355 Disease Relevance 0.77 Pain Relevance 0
The classical example is the liver, with K8/K18 representing the characteristic and only keratin pair of normal hepatocytes.
K8 Binding (liver) of in hepatocytes
2) Confidence 0.22 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.26 Pain Relevance 0
Specific binding to CK8, CK18, and CK19 was noted in the sera of ASA-intolerant asthma subjects.


CK8 Binding (binding) of associated with asthma and aspirin
3) Confidence 0.19 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 0.42 Pain Relevance 0.05
Furthermore, K8/K18 occur—together with other keratins—in various pseudostratified (e.g. respiratory) and complex (e.g. glandular) epithelia and in the urothelium; in these composite epithelial tissues, K8 and K18 are often most prominent in the lumen-lining cells.
K8 Binding (prominent) of in lumen
4) Confidence 0.19 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0
K8/K18: primary keratins of simple epithelial cells
K8 Binding (keratins) of in epithelial cells
5) Confidence 0.19 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.99 Pain Relevance 0
KRT18 is a type I cytokeratin, while KRT8 is a type II keratin that typically dimerises with keratin 18 to form intermediate filaments in the cytoplasm of cells.
KRT8 Binding (dimerises) of in filaments
6) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0

General Comments

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