INT230136

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (OSBPL8, ABCA1) lipid binding (OSBPL8) small molecule metabolic process (ABCA1)
Golgi apparatus (ABCA1) ATPase activity (ABCA1) plasma membrane (ABCA1)
Anatomy Link Frequency
macrophages 2
OSBPL8 (Homo sapiens)
ABCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 62.16 Quite High
cINOD 3 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 9 86.24 High High
Alzheimer's Dementia 5 50.00 Quite Low
Stress 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it has been recently reported that ORP8 modulates expression levels of the cholesterol-efflux pump ATP-binding cassette A1 (ABCA1) in macrophages [43], and therefore it is possible that ORPs also contribute to the activity of LXRs by modulating cellular levels of LXR-target genes.
ORP8 Spec (possible) Regulation (modulates) of ABCA1 Binding (binding) of in macrophages
1) Confidence 0.07 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.17 Pain Relevance 0.03

General Comments

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