INT230137

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.15
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OSBP, APP) cytoplasm (OSBP, APP) transport (OSBP)
extracellular matrix organization (APP) DNA binding (APP) lipid binding (OSBP)
OSBP (Homo sapiens)
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 5 50.72 Quite High
cINOD 15 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 45 74.80 Quite High
Alzheimer's Dementia 25 50.00 Quite Low
Adhesions 5 46.16 Quite Low
Stress 5 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then postulated that OSBP1 might modulate a specific intracellular pool of APP.
OSBP1 Spec (might) Regulation (modulate) of APP
1) Confidence 0.59 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
These results suggest that OSBP1 might act to exclude a specific population of APP heterodimers from organelles containing high levels of OSBP1, which is likely governed by changes in subcellular cholesterol distribution.
OSBP1 Regulation (population) of APP
2) Confidence 0.50 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
These results suggest that OSBP1 may modulate APP processing via complex mechanisms, perhaps by affecting both the non-amyloidogenic trafficking of APP and the clearance of sAPP?.
OSBP1 Regulation (affecting) of sAPP
3) Confidence 0.43 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
These results suggest that OSBP1 may modulate APP processing via complex mechanisms, perhaps by affecting both the non-amyloidogenic trafficking of APP and the clearance of sAPP?.
OSBP1 Spec (may) Regulation (modulate) of APP
4) Confidence 0.30 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
The present study investigated whether OSBP1, the archetypal member of the family, could alone modulate APP processing.
OSBP1 Regulation (modulate) of APP
5) Confidence 0.26 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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