INT230149

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.32
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APP, NOTCH2) extracellular region (APP, NOTCH2) plasma membrane (APP, NOTCH2)
cell differentiation (NOTCH2) nucleoplasm (NOTCH2) Golgi apparatus (APP)
Anatomy Link Frequency
plasma 1
APP (Homo sapiens)
NOTCH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 12 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 36 88.88 High High
Alzheimer's Dementia 20 50.00 Quite Low
Adhesions 4 31.76 Quite Low
Stress 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to binding to Notch2, APP is known to bind to many other proteins and therefore other types of APP heterodimers can potentially exist.
APP Binding (binding) of Notch2
1) Confidence 0.32 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.08 Pain Relevance 0
In addition to binding to Notch2, APP is known to bind to many other proteins and therefore other types of APP heterodimers can potentially exist.
APP Binding (binding) of Notch2
2) Confidence 0.24 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.09 Pain Relevance 0
In addition to binding to Notch2, APP is known to bind to many other proteins and therefore other types of APP heterodimers can potentially exist.
APP Binding (bind) of Notch2
3) Confidence 0.23 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.08 Pain Relevance 0
Interaction between APP and Notch2 was recently described and shown to occur in the ER, Golgi and at the plasma membrane [34,35].
APP Binding (Interaction) of Notch2 in plasma
4) Confidence 0.23 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.07 Pain Relevance 0

General Comments

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