INT230161

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.25
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (OSBP) transport (OSBP) Golgi apparatus (OSBP)
cytoplasm (OSBP)
OSBP (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 18 60.96 Quite High
Kinase C 6 33.12 Quite Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 6 78.28 Quite High
Stress 6 60.24 Quite High
Disease 54 58.48 Quite High
Alzheimer's Dementia 30 50.00 Quite Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the case of OSBP1, the LBD binds cholesterol and its catabolic derivative, 25-hydroxycholesterol (25OH) [22,23].
OSBP1 Binding (binds) of
1) Confidence 0.47 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0.06
When OSBP1 was not overexpressed, 25OH had no effect on the localization of the APP-Notch2 dimers, perhaps because basal levels of OSBP1 were not high enough to counteract the effects of 25OH binding to other ORPs or LXRs.
OSBP1 Binding (binding) of
2) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.05 Pain Relevance 0
For evaluation of OSBP1, APP, and APP-CTFs expression levels in HEK-APPNFEV, cell monolayers were washed twice with ice-cold PBS and lysed in PBS containing 1% Triton X-100, 1 mM PMSF and Complete protease inhibitor cocktail (Roche, Indianapolis, IN) for 30 min on ice.
OSBP1 Binding (evaluation) of
3) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
When bound to cholesterol alone, OSBP1 exists in the cytoplasm and ER, where it also binds two phosphatases, the serine/threonine phosphatase PP2A and a PTPPBS class tyrosine phosphatase.
OSBP1 Binding (bound) of
4) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
OSBP1 binds oxysterols as well as cholesterol, and therefore this work also provides further insight into the relationship between cholesterol and APP metabolism.
OSBP1 Binding (binds) of
5) Confidence 0.35 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
In addition, OSBP1 itself can traffic between the ER/cytoplasm and the Golgi depending on whether it is bound to cholesterol or 25OH.
OSBP1 Binding (bound) of
6) Confidence 0.35 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.08 Pain Relevance 0

General Comments

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