INT230194

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.81
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
gonads 2
PISRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 10 89.32 High High
Blepharophimosis 2 88.16 High High
Glycogen Storage Disease 6 80.80 Quite High
Symphalangism 2 78.72 Quite High
Ectodermal Dysplasia 6 76.08 Quite High
Disease 190 73.52 Quite High
Animal Diseases 14 72.12 Quite High
Ceroid Lipofuscinosis 2 44.44 Quite Low
Muscle Disease 2 30.88 Quite Low
Cleidocranial Dysplasia 2 22.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In goats with XX sex-reversed gonads, the expression of PISRT1 decreases between 36 days post-coitus (dpc) and 40 dpc accompanied with an increase in SOX9 expression (Pailhoux et al. 2001).
Negative_regulation (decreases) of Gene_expression (expression) of PISRT1 in gonads
1) Confidence 0.30 Published 2008 Journal Mamm Genome Section Body Doc Link PMC2323435 Disease Relevance 0.25 Pain Relevance 0
In normal circumstances, therefore, PISRT1 functions by inhibiting SOX9 as an antitestis gene while FOXL2 promotes ovarian development.
Negative_regulation (inhibiting) of Gene_expression (functions) of PISRT1
2) Confidence 0.29 Published 2008 Journal Mamm Genome Section Body Doc Link PMC2323435 Disease Relevance 0.56 Pain Relevance 0

General Comments

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