INT23021

Context Info Confidence 0.65 First Reported 1990 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 3 Disease Relevance 1.82 Pain Relevance 2.10

nucleus (SP5) intracellular (SP5) DNA binding (SP5)

SP5 (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 2 99.40 psoriasis 1 99.24 Glutamate receptor 2 99.14 gABA 2 97.96 Pain 5 97.56 Arthritis 2 96.76 Triptan 2 95.84 Migraine 6 95.60 headache 2 91.12 depression 2 86.88

Disease Link Frequency Relevance Heat Psoriatic Arthritis 3 99.24 Nociception 4 99.00 Pain 4 97.56 Headache 6 95.60 Arthralgia 1 94.04 Increased Venous Pressure Under Development 2 91.12 Depression 2 86.88 Disease 1 85.36 INFLAMMATION 2 64.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

[Therapeutic use of splenopentin (DA SP-5) in patients with psoriasis arthropathica].

Gene_expression (use) of SP-5 associated with psoriasis

1) Confidence 0.65 Published 1990 Journal Dermatol Monatsschr Section Title Doc Link 2365110 Disease Relevance 0.38 Pain Relevance 0.23

This review discusses the importance of c-fos expression within Sp5C as a marker of cephalic nociception, the different cephalic pain models that induce c-fos within Sp5C, the receptors involved and their potential role as targets for anti-migraine drugs.

Gene_expression (expression) of Sp5C associated with nociception, pain and migraine

2) Confidence 0.27 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11245884 Disease Relevance 0.74 Pain Relevance 0.89

Up-to-date there is evidence that at least ten receptors (5-HT(1B), 5-HT(1D), 5-HT(lF), 5-HT(2B), NK-1, GABA(A), NMDA, AMPA, class III metabotropic glutamate receptors, and opioids mu receptors) modulate c-fos expression within Sp5C.

Gene_expression (expression) of Sp5C associated with gaba, glutamate receptor and opioid

3) Confidence 0.27 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11245884 Disease Relevance 0.70 Pain Relevance 0.98

General Comments

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