INT23021

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Context Info
Confidence 0.65
First Reported 1990
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.82
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SP5) intracellular (SP5) DNA binding (SP5)
SP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 2 99.40 Very High Very High Very High
psoriasis 1 99.24 Very High Very High Very High
Glutamate receptor 2 99.14 Very High Very High Very High
gABA 2 97.96 Very High Very High Very High
Pain 5 97.56 Very High Very High Very High
Arthritis 2 96.76 Very High Very High Very High
Triptan 2 95.84 Very High Very High Very High
Migraine 6 95.60 Very High Very High Very High
headache 2 91.12 High High
depression 2 86.88 High High
Disease Link Frequency Relevance Heat
Psoriatic Arthritis 3 99.24 Very High Very High Very High
Nociception 4 99.00 Very High Very High Very High
Pain 4 97.56 Very High Very High Very High
Headache 6 95.60 Very High Very High Very High
Arthralgia 1 94.04 High High
Increased Venous Pressure Under Development 2 91.12 High High
Depression 2 86.88 High High
Disease 1 85.36 High High
INFLAMMATION 2 64.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Therapeutic use of splenopentin (DA SP-5) in patients with psoriasis arthropathica].
Gene_expression (use) of SP-5 associated with psoriasis
1) Confidence 0.65 Published 1990 Journal Dermatol Monatsschr Section Title Doc Link 2365110 Disease Relevance 0.38 Pain Relevance 0.23
This review discusses the importance of c-fos expression within Sp5C as a marker of cephalic nociception, the different cephalic pain models that induce c-fos within Sp5C, the receptors involved and their potential role as targets for anti-migraine drugs.
Gene_expression (expression) of Sp5C associated with nociception, pain and migraine
2) Confidence 0.27 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11245884 Disease Relevance 0.74 Pain Relevance 0.89
Up-to-date there is evidence that at least ten receptors (5-HT(1B), 5-HT(1D), 5-HT(lF), 5-HT(2B), NK-1, GABA(A), NMDA, AMPA, class III metabotropic glutamate receptors, and opioids mu receptors) modulate c-fos expression within Sp5C.
Gene_expression (expression) of Sp5C associated with gaba, glutamate receptor and opioid
3) Confidence 0.27 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11245884 Disease Relevance 0.70 Pain Relevance 0.98

General Comments

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