INT230238

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.27
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pik3cb) signal transduction (Pik3cb) cell adhesion (Pik3cb)
nucleus (Pik3cb) cytoplasm (Pik3cb)
Anatomy Link Frequency
neuronal 1
neurons 1
heart 1
Pik3cb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 24 95.36 Very High Very High Very High
Glutamate 6 88.88 High High
Hippocampus 5 85.92 High High
Neurotransmitter 1 76.88 Quite High
nMDA receptor 3 72.32 Quite High
Morphine 53 62.96 Quite High
diabetic neuropathy 47 56.76 Quite High
Codeine 1 55.04 Quite High
Kinase C 2 50.88 Quite High
Central nervous system 6 23.76 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 248 99.76 Very High Very High Very High
Apoptosis 23 99.76 Very High Very High Very High
Death 19 99.72 Very High Very High Very High
Stress 15 95.76 Very High Very High Very High
Pain 24 95.36 Very High Very High Very High
Convulsion 1 95.12 Very High Very High Very High
Diabetic Cardiomyopathies 105 86.40 High High
Infection 10 83.16 Quite High
Neuropathy 6 82.64 Quite High
Myocardial Infarction 57 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, estrogens were shown to limit neuronal damage and death, possibly by signaling through PI3K, PKC, ERK or glycogen synthase kinase 3-?
PI3K Binding (signaling) of in neuronal associated with death
1) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.39 Pain Relevance 0.39
During Western blot studies, subsequent Shh transfection of the respective siRNA transfected cells showed that PI3K/Akt abrogation failed to block Shh induced iNOS expression (Figure 3D; lane-3).
PI3K Binding (abrogation) of
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0
This is the reason why NMDA is able to rescue granule neurons from apoptosis induced by PI3K inhibition with LY-294002.
PI3K Binding (inhibition) of in neurons associated with apoptosis
3) Confidence 0.18 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.15 Pain Relevance 0.04
The diabetic heart is resistant to ischemic preconditioning because of diabetes-associated impairment of phosphatidylinositol 3-kinase (PI3K)-Akt signaling.
PI3K Neg (impairment) Binding (impairment) of in heart associated with diabetes mellitus
4) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.10 Pain Relevance 0
Expression of genes associated with the PI3K, PKC and nuclear factor kappa B (NFKB) pathways were induced with respect to those found in saline treated animals on average by a factor of 3.8, 4 and 4.6 respectively by each of the viruses included in this study.
PI3K Binding (associated) of
5) Confidence 0.11 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.08 Pain Relevance 0.03
the presence of insulin and stimulates p38 MAP-kinase and PI-3 kinase activity
PI-3 kinase Binding (activity) of
6) Confidence 0.05 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.54 Pain Relevance 0.06

General Comments

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