INT23026

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Context Info
Confidence 0.42
First Reported 1990
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.42
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
spinal 2
blood 2
diencephalon 2
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 3 100.00 Very High Very High Very High
agonist 17 99.98 Very High Very High Very High
fluoxetine 19 99.12 Very High Very High Very High
wide dynamic range 2 99.04 Very High Very High Very High
antagonist 8 96.32 Very High Very High Very High
Eae 4 94.64 High High
Serotonin 7 89.76 High High
c fibre 3 88.48 High High
unmyelinated 1 83.76 Quite High
Morphine 2 83.12 Quite High
Disease Link Frequency Relevance Heat
Hypotension 1 93.04 High High
Nociception 2 75.00 Quite High
Body Weight 1 74.08 Quite High
Heart Rate Under Development 1 66.48 Quite High
Increased Venous Pressure Under Development 1 57.20 Quite High
Dyspnea 1 45.12 Quite Low
Anxiety Disorder 1 41.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Long-term exposure to fluoxetine produces a desensitization of hypothalamic postsynaptic 5-hydroxytryptamine (5-HT)1A receptors, indicated by a substantial inhibition of the 5-HT1A receptor-mediated stimulation of oxytocin and adrenocorticotropic hormone (ACTH) secretion.
Negative_regulation (inhibition) of Positive_regulation (stimulation) of 5-HT1A associated with fluoxetine
1) Confidence 0.42 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918559 Disease Relevance 0 Pain Relevance 0.38
Stimulation of 5-HT1A receptors is known to decrease the arterial blood pressure in anaesthetized rats, cats and dogs.
Negative_regulation (decrease) of Positive_regulation (Stimulation) of 5-HT1A in blood
2) Confidence 0.41 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2366880 Disease Relevance 0.22 Pain Relevance 0.13
Subsequent systemic fluoxetine, sertraline, or paroxetine, produced a 50% decrease in extracellular 5-HT in the diencephalon, presumably due to activation of the 5-HT1A somatodendritic autoreceptors.
Negative_regulation (decrease) of Positive_regulation (activation) of 5-HT1A in diencephalon associated with fluoxetine
3) Confidence 0.41 Published 1995 Journal Synapse Section Abstract Doc Link 7570354 Disease Relevance 0 Pain Relevance 0.77
These results indicate that activation of inwardly rectifying K+ channels and inhibition of voltage-activated calcium channels by 5-HT1A receptor activation do not constitute a main pathway for presynaptic inhibition by 5-HT of glycinergic synaptic transmission.
Negative_regulation (inhibition) of Positive_regulation (activation) of 5-HT1A associated with calcium channel
4) Confidence 0.41 Published 1995 Journal J. Neurophysiol. Section Abstract Doc Link 7608765 Disease Relevance 0 Pain Relevance 0.48
These results suggest that stimulation of 5-HT1A receptors inhibits the activity in spinal wide dynamic range neurones after repeated electrical stimulation.
Negative_regulation (inhibits) of Positive_regulation (stimulation) of 5-HT1A in spinal associated with wide dynamic range
5) Confidence 0.41 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9016920 Disease Relevance 0.13 Pain Relevance 0.53
These results demonstrate that activation of 5-HT1A and 5-HT2 receptors can excite or inhibit populations of NTS neurones.
Negative_regulation (inhibit) of Positive_regulation (activation) of 5-HT1A
6) Confidence 0.41 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225274 Disease Relevance 0 Pain Relevance 0.16
These results demonstrate that, under the present experimental conditions, activation of central 5-HT1A, 5-HT1B, and 5-HT2 receptors reduced ethanol intake and reinforced behaviour in an operant paradigm.
Negative_regulation (reduced) of Positive_regulation (activation) of 5-HT1A
7) Confidence 0.41 Published 1998 Journal Alcohol Section Abstract Doc Link 9744857 Disease Relevance 0.07 Pain Relevance 0.55
5-HT1A receptor agonists decrease 5-hydroxytryptamine (5-HT) terminal release by activating somatodendritic 5-HT1A autoreceptors.
Negative_regulation (decrease) of Positive_regulation (activating) of 5-HT1A associated with agonist
8) Confidence 0.41 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11104831 Disease Relevance 0 Pain Relevance 0.24
The results obtained indicate that: (a) activation of 5-HT1A receptors stimulated PRL secretion on day 16 and inhibited it on day 23; activation of 5-HT2 receptors stimulated PRL secretion on days 16 and 23, whereas activation of 5-HT3 receptors inhibited PRL release only on day 23; (b) activation of AMPA receptors inhibited PRL secretion on day 23, but not on day 16 and (c) a cross-talk is apparent between 5-HT2 and AMPA receptors in the regulation of PRL secretion, the stimulatory effect of DOI being blocked by AMPA.
Negative_regulation (inhibited) of Positive_regulation (activation) of 5-HT1A
9) Confidence 0.41 Published 2001 Journal J. Physiol. Biochem. Section Abstract Doc Link 11800286 Disease Relevance 0 Pain Relevance 0.47

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