INT230293

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 0.83
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (HIST2H2AC) nucleus (HIST2H2AC) DNA binding (HIST2H2AC)
HIST2H2AC (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 4 58.96 Quite High
tolerance 1 32.68 Quite Low
Neuropeptide 5 5.00 Very Low Very Low Very Low
IPN 5 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Enkephalin 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
bradykinin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 17 99.62 Very High Very High Very High
Bacterial Respiratory Disease 55 87.56 High High
Parasitemia 4 70.80 Quite High
Injury 5 64.16 Quite High
Blister 1 63.68 Quite High
Hemorrhage 4 62.08 Quite High
Malaria 109 50.00 Quite Low
Sprains And Strains 22 46.80 Quite Low
Helminth Infection 1 12.52 Low Low
Fungal Infection 9 6.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunization of the rabbit for H2A.Z antibody production used in this study was carried out in strict accordance with the regulations and recommendations of the Dutch Law for Animal Experimentation (WOD).
Gene_expression (production) of H2A associated with immunization
1) Confidence 0.27 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3002978 Disease Relevance 0.36 Pain Relevance 0.06
Generation of polyclonal H2A.Z antibody
Gene_expression (antibody) of H2A
2) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3002978 Disease Relevance 0.13 Pain Relevance 0
Markedly, these changes occurred in regions with low H2A.Z levels and were not accompanied by H3K4me3.
Gene_expression (levels) of H2A
3) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3002978 Disease Relevance 0 Pain Relevance 0
Another intriguing example of H2A.Z-independent H3K9ac (and H3K4me3) marking during early stages of the iRBC cycle (Figure S10) can be observed about 2 kb upstream of antigenic variation genes located at the very end of the chromosomes (upsB type var genes). var genes have been shown to be expressed in a mutually exclusive manner during ring stage [41].
Gene_expression (example) of H2A
4) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3002978 Disease Relevance 0 Pain Relevance 0
DNA DSBs induce early phosphorylation of yeast H2A (major H2A closer to mammalian H2AX) and human H2AX histones on a conserved serine residue located in the SQ motif at C terminus, producing ?
Gene_expression (major) of H2A
5) Confidence 0.04 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
DNA DSBs induce early phosphorylation of yeast H2A (major H2A closer to mammalian H2AX) and human H2AX histones on a conserved serine residue located in the SQ motif at C terminus, producing ?
Gene_expression (histones) of H2A
6) Confidence 0.04 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
Their existence in the E. histolytica Pathema database [38] were confirmed by BLAST using yeast H2A and human H2AX protein sequences as queries.
Gene_expression (using) of H2A
7) Confidence 0.04 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
DNA DSBs induce early phosphorylation of yeast H2A (major H2A closer to mammalian H2AX) and human H2AX histones on a conserved serine residue located in the SQ motif at C terminus, producing ?
Gene_expression (histones) of H2A
8) Confidence 0.04 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
DNA DSBs induce early phosphorylation of yeast H2A (major H2A closer to mammalian H2AX) and human H2AX histones on a conserved serine residue located in the SQ motif at C terminus, producing ?
Gene_expression (closer) of H2A
9) Confidence 0.04 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
There are several types of histone of which H2A, H2B, H3 and H4 are the core histones that form the nucleosome, and H1 and H5 are the linker histones.
Gene_expression (types) of H2A
10) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866484 Disease Relevance 0.34 Pain Relevance 0

General Comments

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