INT230293

Context Info Confidence 0.27 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 10 Disease Relevance 0.83 Pain Relevance 0.06

chromosome (HIST2H2AC) nucleus (HIST2H2AC) DNA binding (HIST2H2AC)

HIST2H2AC (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 4 58.96 tolerance 1 32.68 Neuropeptide 5 5.00 IPN 5 5.00 Potency 5 5.00 Inflammation 2 5.00 cytokine 1 5.00 Enkephalin 1 5.00 metalloproteinase 1 5.00 bradykinin 1 5.00

Disease Link Frequency Relevance Heat Immunization 17 99.62 Bacterial Respiratory Disease 55 87.56 Parasitemia 4 70.80 Injury 5 64.16 Blister 1 63.68 Hemorrhage 4 62.08 Malaria 109 50.00 Sprains And Strains 22 46.80 Helminth Infection 1 12.52 Fungal Infection 9 6.52

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The immunization of the rabbit for H2A.Z antibody production used in this study was carried out in strict accordance with the regulations and recommendations of the Dutch Law for Animal Experimentation (WOD).

Gene_expression (production) of H2A associated with immunization

1) Confidence 0.27 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3002978 Disease Relevance 0.36 Pain Relevance 0.06

Generation of polyclonal H2A.Z antibody

Gene_expression (antibody) of H2A

2) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3002978 Disease Relevance 0.13 Pain Relevance 0

Markedly, these changes occurred in regions with low H2A.Z levels and were not accompanied by H3K4me3.

Gene_expression (levels) of H2A

3) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3002978 Disease Relevance 0 Pain Relevance 0

Another intriguing example of H2A.Z-independent H3K9ac (and H3K4me3) marking during early stages of the iRBC cycle (Figure S10) can be observed about 2 kb upstream of antigenic variation genes located at the very end of the chromosomes (upsB type var genes). var genes have been shown to be expressed in a mutually exclusive manner during ring stage [41].

Gene_expression (example) of H2A

4) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3002978 Disease Relevance 0 Pain Relevance 0

DNA DSBs induce early phosphorylation of yeast H2A (major H2A closer to mammalian H2AX) and human H2AX histones on a conserved serine residue located in the SQ motif at C terminus, producing ?

Gene_expression (major) of H2A

5) Confidence 0.04 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0

DNA DSBs induce early phosphorylation of yeast H2A (major H2A closer to mammalian H2AX) and human H2AX histones on a conserved serine residue located in the SQ motif at C terminus, producing ?

Gene_expression (histones) of H2A

6) Confidence 0.04 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0

Their existence in the E. histolytica Pathema database [38] were confirmed by BLAST using yeast H2A and human H2AX protein sequences as queries.

Gene_expression (using) of H2A

7) Confidence 0.04 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0

DNA DSBs induce early phosphorylation of yeast H2A (major H2A closer to mammalian H2AX) and human H2AX histones on a conserved serine residue located in the SQ motif at C terminus, producing ?

Gene_expression (histones) of H2A

8) Confidence 0.04 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0

DNA DSBs induce early phosphorylation of yeast H2A (major H2A closer to mammalian H2AX) and human H2AX histones on a conserved serine residue located in the SQ motif at C terminus, producing ?

Gene_expression (closer) of H2A

9) Confidence 0.04 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0

There are several types of histone of which H2A, H2B, H3 and H4 are the core histones that form the nucleosome, and H1 and H5 are the linker histones.

Gene_expression (types) of H2A

10) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866484 Disease Relevance 0.34 Pain Relevance 0

General Comments

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