INT230296

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.15
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (H2AFX) histone binding (H2AFX) chromosome (H2AFX)
nucleus (H2AFX) enzyme binding (H2AFX) cell cycle (H2AFX)
H2AFX (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 12 89.60 High High
IPN 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
GABA receptor 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dna Repair-deficiency Disorders 1 78.56 Quite High
Freckles 1 76.00 Quite High
Sprains And Strains 19 5.00 Very Low Very Low Very Low
Stress 7 5.00 Very Low Very Low Very Low
Amebiasis 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Fungal Infection 3 5.00 Very Low Very Low Very Low
Immunization 2 5.00 Very Low Very Low Very Low
Parkinson's Disease 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like Chk2 phosphorylation, H2AX phosphorylation was induced by compound 15, but not by compound 13 (Figure 6D).
Neg (not) Positive_regulation (induced) of Phosphorylation (phosphorylation) of H2AX
1) Confidence 0.18 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2583946 Disease Relevance 0.15 Pain Relevance 0.04
Early phosphorylation of E. histolytica H2AX histones after UV-C irradiation was consistent with DNA DSBs formation, suggesting chromatin remodeling and recruitment of histone-phosphorylating enzymes, as observed in other eukaryotic systems [22].
Positive_regulation (histones) of Phosphorylation (phosphorylation) of H2AX
2) Confidence 0.11 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
DNA DSBs induce early phosphorylation of yeast H2A (major H2A closer to mammalian H2AX) and human H2AX histones on a conserved serine residue located in the SQ motif at C terminus, producing ?
Positive_regulation (induce) of Phosphorylation (phosphorylation) of H2AX
3) Confidence 0.10 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0

General Comments

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