INT23030

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Context Info
Confidence 0.61
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 9.24
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth)
Anatomy Link Frequency
parathyroid 7
cortical bone 1
Pth (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 7 99.34 Very High Very High Very High
Enkephalin 1 91.44 High High
depression 6 80.80 Quite High
fibrosis 25 79.04 Quite High
Inflammation 36 76.32 Quite High
imagery 34 66.40 Quite High
withdrawal 1 63.52 Quite High
substance P 2 55.12 Quite High
palliative 4 25.00 Low Low
Analgesic 2 10.00 Low Low
Disease Link Frequency Relevance Heat
Hypercalcemia 45 99.56 Very High Very High Very High
Cancer 72 99.40 Very High Very High Very High
Pain 6 99.34 Very High Very High Very High
Rickets 24 94.00 High High
Chronic Renal Failure 3 93.44 High High
Hypophosphatemia 8 92.84 High High
Disease 123 91.92 High High
Osteoporosis 18 86.96 High High
Parathyroid Cancer 7 86.56 High High
Breast Cancer 8 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A combination of ketamine plus xylazine significantly increased serum PTH, but not serum calcium concentrations.
Neg (not) Positive_regulation (increased) of serum PTH
1) Confidence 0.61 Published 2007 Journal Vet Anaesth Analg Section Body Doc Link 17565572 Disease Relevance 0 Pain Relevance 0
Chronic elevations of PTH from vitamin D deficiency are associated with increased cortical bone resorption and porosity.
Positive_regulation (elevations) of PTH in cortical bone associated with hypercalcemia
2) Confidence 0.52 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.19 Pain Relevance 0
On day 0, mice receiving Low-Ca had increased serum parathyroid hormone (PTH) and tartrate-resistant acid phosphatase 5b levels, indicating secondary hyperparathyroidism and high bone turnover, which was maintained until day 17.
Positive_regulation (increased) of PTH in parathyroid associated with hypercalcemia
3) Confidence 0.45 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17909065 Disease Relevance 1.25 Pain Relevance 0
On day 0, mice receiving Low-Ca had increased serum parathyroid hormone (PTH) and tartrate-resistant acid phosphatase 5b levels, indicating secondary hyperparathyroidism and high bone turnover, which was maintained until day 17.
Positive_regulation (increased) of parathyroid hormone in parathyroid associated with hypercalcemia
4) Confidence 0.45 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17909065 Disease Relevance 1.24 Pain Relevance 0
In mild vitamin D deficiency, the elevation of serum PTH increases the conversion of 25(OH)D to 1,25(OH)D to compensate for the insufficient 25(OH)D available; however, elevation in PTH increases bone resorption, leading to additional bone loss [19].
Positive_regulation (elevation) of serum PTH associated with hypercalcemia
5) Confidence 0.35 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.97 Pain Relevance 0.07
In mild vitamin D deficiency, the elevation of serum PTH increases the conversion of 25(OH)D to 1,25(OH)D to compensate for the insufficient 25(OH)D available; however, elevation in PTH increases bone resorption, leading to additional bone loss [19].
Positive_regulation (elevation) of PTH associated with hypercalcemia
6) Confidence 0.35 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 1.10 Pain Relevance 0.08
The pattern of change in these markers of bone remodeling is different from the pattern documented as occurring with antiresorptive therapies, such as bisphosphonates and selective estrogen receptor modulators (which decrease markers of bone resorption and bone formation), or with anabolic therapy such as PTH (which increases markers of bone resorption and bone formation).25 In patients treated with SR, there was a remodeling marker divergence (increase in bone formation, decrease in bone resorption), which underscores the difference in the mechanism of action of SR compared with traditional antiresorptive agents and paratormon.
Positive_regulation (increases) of PTH associated with hypercalcemia
7) Confidence 0.33 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.40 Pain Relevance 0.03
Serum intact PTH was elevated (1020 pg/ml; normal values, 12-62 pg/ml), but her serum calcium was normal (total=9.4 mg/dl, nv 8.5-10.5; ionized=5.0 mg/dl, nv 4.2-5.4) due to the coexistence of chronic renal failure. 99mTc-MIBI scintigraphy revealed a single focus of sestamibi accumulation in the left retrosternal location, which turned out to be an intrathoracic parathyroid adenoma at surgical exploration.
Positive_regulation (elevated) of PTH in parathyroid associated with chronic renal failure and parathyroid cancer
8) Confidence 0.25 Published 2010 Journal ScientificWorldJournal Section Abstract Doc Link 20454761 Disease Relevance 0.81 Pain Relevance 0.19
Serum calcium was elevated between 10.2–10.7 mg/dL (normal range 8.5–10.2 mg/dL) and serum intact parathyroid hormone (PTH) was mildly elevated at 69 pg/mL (normal range 15–65 pg/mL) suggesting primary hyperparathyroidism.
Positive_regulation (elevated) of PTH in parathyroid associated with hypercalcemia
9) Confidence 0.11 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2678126 Disease Relevance 0.48 Pain Relevance 0.13
Serum calcium was elevated between 10.2–10.7 mg/dL (normal range 8.5–10.2 mg/dL) and serum intact parathyroid hormone (PTH) was mildly elevated at 69 pg/mL (normal range 15–65 pg/mL) suggesting primary hyperparathyroidism.
Positive_regulation (elevated) of parathyroid hormone in parathyroid associated with hypercalcemia
10) Confidence 0.10 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2678126 Disease Relevance 0.48 Pain Relevance 0.13
In addition, membranes expressing rPhex-WT, rPhex-3'M, and the empty vector hydrolyzed parathyroid hormone-(1-34), indicating the lack of Phex-specific cleavage of parathyroid hormone.
Positive_regulation (cleavage) of parathyroid hormone in parathyroid
11) Confidence 0.07 Published 2001 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 11551862 Disease Relevance 0.37 Pain Relevance 0.09
The result is hypercalcemia associated with inappropriately normal or mildly elevated levels of parathyroid hormone.
Positive_regulation (levels) of parathyroid hormone in parathyroid associated with hypercalcemia
12) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2939531 Disease Relevance 1.24 Pain Relevance 0.08
The 2 patients who showed BGP levels below 10 ng/ml had tumor weights of only 470 mg and 240 mg, respectively, and revealed no improvement of pain postoperatively, although their mPTH levels were increased.
Positive_regulation (increased) of mPTH associated with pain and cancer
13) Confidence 0.00 Published 1990 Journal World J Surg Section Abstract Doc Link 2368448 Disease Relevance 0.72 Pain Relevance 0.18

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