INT230307

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (HIST2H2AC) nucleus (HIST2H2AC) DNA binding (HIST2H2AC)
HIST2H2AC (Homo sapiens)
Pain Link Frequency Relevance Heat
IPN 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 82.08 Quite High
Targeted Disruption 3 73.60 Quite High
Amebiasis 6 56.00 Quite High
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Immunization 3 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Malaria 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DNA DSBs induce early phosphorylation of yeast H2A (major H2A closer to mammalian H2AX) and human H2AX histones on a conserved serine residue located in the SQ motif at C terminus, producing ?
Phosphorylation (phosphorylation) of H2A
1) Confidence 0.05 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
Particularly, Saccharomyces cerevisiae H2A and Homo sapiens H2AX histones are rapidly phosphorylated in the chromatin micro-environment surrounding DNA DSBs, inducing nucleosome remodeling to promote accumulation of checkpoint and DNA repair proteins at these sites [8].
Phosphorylation (phosphorylated) of H2A
2) Confidence 0.05 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0.21 Pain Relevance 0
DNA DSBs induce early phosphorylation of yeast H2A (major H2A closer to mammalian H2AX) and human H2AX histones on a conserved serine residue located in the SQ motif at C terminus, producing ?
Phosphorylation (phosphorylation) of H2A
3) Confidence 0.05 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0

General Comments

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