INT230323

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 0.51
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RAD51) mitochondrion (RAD51) nucleus (RAD51)
cytoplasm (RAD51)
Anatomy Link Frequency
nucleus 1
RAD51 (Homo sapiens)
Pain Link Frequency Relevance Heat
IPN 6 7.44 Low Low
Pain 8 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 142 97.68 Very High Very High Very High
Shock 12 85.08 High High
Hypersensitivity 10 48.08 Quite Low
Sprains And Strains 16 30.52 Quite Low
Infection 26 15.20 Low Low
Cancer 28 5.00 Very Low Very Low Very Low
Targeted Disruption 20 5.00 Very Low Very Low Very Low
Amebiasis 12 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Immunization 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with the Western blot results, EhRAD51 was detected at low levels in the cytosol of non-irradiated trophozoites (Fig. 6, panels A-D), whereas at 30 min after UV-C irradiation we noted a dramatic accumulation of cytoplasmic EhRAD51 protein.
Positive_regulation (accumulation) of EhRAD51
1) Confidence 0.58 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
In agreement with the RT-PCR results, Western blot assays showed a dramatic increase of EhRAD51 in cytoplasm and nucleus, 30 min after DNA breaks were introduced into the E. histolytica genome.
Positive_regulation (increase) of EhRAD51 in nucleus
2) Confidence 0.58 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
In silico analysis demonstrated that the predicted EhRAD51 protein contains all functional and structural motifs that are important for RECA/RAD51 recombinases activities.
Positive_regulation (important) of RECA/RAD51
3) Confidence 0.48 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
Results showed that incubation of rEhRAD51 with ssDNA and dsDNA probes resulted in five DNA-protein complexes (CI-CV) formation, suggesting that alternative populations of RAD51 protomers were associated to each DNA probes (Fig. 7A and 7B, lanes 2 to 4).
Positive_regulation (populations) of RAD51
4) Confidence 0.48 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
Increasing amounts of rEhRAD51 (0, 2.5, 5 and 7.5 ?
Positive_regulation (Increasing) of rEhRAD51
5) Confidence 0.39 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
Our findings showed that EhRAD51 was overexpressed in response to UV-C irradiation, and distributed in both nuclear and cytoplasmic compartments.


Positive_regulation (distributed) of EhRAD51
6) Confidence 0.39 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
XRCC4, XRCC5, ERCC2, RAD17, and RAD51, which are all key genes in DNA replication and repair [22-25], were induced.
Positive_regulation (induced) of RAD51
7) Confidence 0.13 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.42 Pain Relevance 0
RAD51 paralogs and BRCA2) are required for RAD51 foci formation (46,47).
Positive_regulation (required) of RAD51
8) Confidence 0.06 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2770670 Disease Relevance 0 Pain Relevance 0
(A) Representative image of cisplatin-induced RAD51 foci.
Positive_regulation (induced) of RAD51
9) Confidence 0.06 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2770670 Disease Relevance 0 Pain Relevance 0
RAD51 paralogs and BRCA2) are required for RAD51 foci formation (46,47).
Positive_regulation (required) of RAD51
10) Confidence 0.06 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2770670 Disease Relevance 0 Pain Relevance 0
Furthermore, we report that RAD51 foci are induced by cisplatin or mitomycin C independently of ERCC1, but that mitomycin C-induced HR measured in a reporter construct is impaired in ERCC1-defective cells.
Neg (independently) Positive_regulation (induced) of RAD51
11) Confidence 0.06 Published 2009 Journal Nucleic Acids Research Section Abstract Doc Link PMC2770670 Disease Relevance 0.09 Pain Relevance 0

General Comments

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