INT23034

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2005
Negated 1
Speculated 2
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 8.75
Pain Relevance 6.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
plasma 3
liver 1
paw 1
body 1
Il1a (Mus musculus)
Pain Link Frequency Relevance Heat
cva 4 100.00 Very High Very High Very High
Morphine 20 99.60 Very High Very High Very High
anesthesia 12 99.56 Very High Very High Very High
Paracetamol 28 99.40 Very High Very High Very High
cytokine 77 99.38 Very High Very High Very High
Inflammation 41 99.04 Very High Very High Very High
narcan 4 98.40 Very High Very High Very High
dexamethasone 4 97.36 Very High Very High Very High
Inflammatory response 2 97.04 Very High Very High Very High
ketamine 6 89.64 High High
Disease Link Frequency Relevance Heat
Fever 4 99.98 Very High Very High Very High
INFLAMMATION 48 99.04 Very High Very High Very High
Disease 30 99.04 Very High Very High Very High
Hepatitis 2 98.28 Very High Very High Very High
Pressure And Volume Under Development 18 97.88 Very High Very High Very High
Cancer 36 96.72 Very High Very High Very High
Sepsis 8 94.96 High High
Endotoxemia 8 94.56 High High
Necrosis 8 90.48 High High
Hypercalcemia 8 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the same time the serum levels of interleukin-1 alpha (IL-1 alpha) were increased.
Positive_regulation (increased) of IL-1 alpha
1) Confidence 0.70 Published 2002 Journal Cytokine Section Abstract Doc Link 12182845 Disease Relevance 0.52 Pain Relevance 0.66
At the same time the serum levels of interleukin-1 alpha (IL-1 alpha) were increased.
Positive_regulation (increased) of interleukin-1 alpha
2) Confidence 0.70 Published 2002 Journal Cytokine Section Abstract Doc Link 12182845 Disease Relevance 0.53 Pain Relevance 0.66
These findings suggest that an increase in serum levels of IL-1 alpha plays an important role in the anti-inflammatory effect of morphine.
Positive_regulation (increase) of IL-1 alpha associated with inflammation and morphine
3) Confidence 0.70 Published 2002 Journal Cytokine Section Abstract Doc Link 12182845 Disease Relevance 0.60 Pain Relevance 0.67
Increase in serum level of interleukin-1 alpha mediates morphine anti-inflammatory effect in carrageenan-induced paw oedema in mice.
Positive_regulation (Increase) of interleukin-1 alpha in paw associated with pressure and volume under development, inflammation and morphine
4) Confidence 0.70 Published 2002 Journal Cytokine Section Title Doc Link 12182845 Disease Relevance 0.54 Pain Relevance 0.63
An increase in IL-1alpha was observed only in the hairless mouse model, also beginning at 6 h post-exposure and continuing to 24 h.
Positive_regulation (increase) of IL-1alpha
5) Confidence 0.67 Published 2000 Journal J Appl Toxicol Section Abstract Doc Link 11428647 Disease Relevance 0.95 Pain Relevance 0.50
Furthermore, neutralization of TNF-alpha delayed the increase in serum IL-1 alpha and liver enzyme levels.
Positive_regulation (increase) of IL-1 alpha in liver
6) Confidence 0.66 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7597709 Disease Relevance 0.35 Pain Relevance 0.78
Both heat-treated and sham mice had elevated plasma IL-1 alpha 2 h after anesthesia and immersion but IL-1 alpha was approximately 3-fold greater in the heated mice, 732 +/- 50 vs. 256 +/- 76 pg/ml (p < 0.01).
Positive_regulation (elevated) of IL-1 alpha in plasma associated with anesthesia
7) Confidence 0.60 Published 1994 Journal Lymphokine Cytokine Res. Section Abstract Doc Link 7858059 Disease Relevance 0.68 Pain Relevance 0.33
Hyperthermia induces IL-1 alpha but does not decrease release of IL-1 alpha or TNF-alpha after endotoxin.
Positive_regulation (induces) of IL-1 alpha associated with fever
8) Confidence 0.60 Published 1994 Journal Lymphokine Cytokine Res. Section Title Doc Link 7858059 Disease Relevance 0.85 Pain Relevance 0.15
Potentiation of interleukin 1 alpha mediated antitumor effects by ketoconazole.
Positive_regulation (Potentiation) of interleukin 1 alpha associated with cva
9) Confidence 0.50 Published 1990 Journal Cancer Res. Section Title Doc Link 2369744 Disease Relevance 0.45 Pain Relevance 0.05
In the present studies, the regulatory role of adrenal hormones on the antitumor activity of recombinant human interleukin 1 alpha (IL-1 alpha) was investigated.
Spec (investigated) Positive_regulation (role) of IL-1 alpha
10) Confidence 0.50 Published 1990 Journal Cancer Res. Section Abstract Doc Link 2369744 Disease Relevance 0.31 Pain Relevance 0
In the present studies, the regulatory role of adrenal hormones on the antitumor activity of recombinant human interleukin 1 alpha (IL-1 alpha) was investigated.
Spec (investigated) Positive_regulation (role) of interleukin 1 alpha
11) Confidence 0.50 Published 1990 Journal Cancer Res. Section Abstract Doc Link 2369744 Disease Relevance 0.30 Pain Relevance 0
Ketoconazole, a potent but transient inhibitor of adrenal steroid hormone biosynthesis, inhibited IL-1 alpha induced increases in plasma corticosterone.
Positive_regulation (increases) of IL-1 alpha in plasma
12) Confidence 0.50 Published 1990 Journal Cancer Res. Section Abstract Doc Link 2369744 Disease Relevance 0.41 Pain Relevance 0
The protective effect of interleukin 1 alpha (IL-1 alpha) in mice with acetaminophen (AAP)-induced hepatitis was investigated.
Positive_regulation (effect) of interleukin 1 alpha associated with paracetamol and hepatitis
13) Confidence 0.49 Published 1993 Journal Cytokine Section Abstract Doc Link 8218930 Disease Relevance 0.17 Pain Relevance 0.42
The protective effect of interleukin 1 alpha (IL-1 alpha) in mice with acetaminophen (AAP)-induced hepatitis was investigated.
Positive_regulation (effect) of IL-1 alpha associated with paracetamol and hepatitis
14) Confidence 0.49 Published 1993 Journal Cytokine Section Abstract Doc Link 8218930 Disease Relevance 0.17 Pain Relevance 0.42
Administration of APAP resulted in an immediate reduction in body temperature as well as elevated serum levels of IL-1 alpha and TNF-alpha that reached a peak at 12 and 16 hr, respectively.
Positive_regulation (elevated) of IL-1 alpha in body associated with paracetamol
15) Confidence 0.44 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7597709 Disease Relevance 0.36 Pain Relevance 0.79
Bone-resorbing human and murine cytokines such as interleukin-6 (IL-6), IL-1 alpha or beta, TGF-alpha, lymphotoxin, and TNF alpha were not significantly increased in ARH-77 mouse sera or marrow plasma, compared with control mice, although ARH-77 cells produce IL-6 and lymphotoxin in vitro.
Neg (not) Positive_regulation (increased) of IL-1 alpha or beta in plasma associated with cytokine
16) Confidence 0.11 Published 1996 Journal Blood Section Abstract Doc Link 8608240 Disease Relevance 0.81 Pain Relevance 0.05
Certain polymorphisms of IL-1A (the gene for IL-1?)
Positive_regulation (polymorphisms) of IL-1A
17) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC555557 Disease Relevance 0.75 Pain Relevance 0.20

General Comments

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