INT23035

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Context Info
Confidence 0.60
First Reported 1990
Last Reported 2006
Negated 0
Speculated 2
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 5.69
Pain Relevance 4.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
macrophages 1
plasma 1
Il1a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 17 100.00 Very High Very High Very High
cytokine 11 100.00 Very High Very High Very High
anesthesia 4 100.00 Very High Very High Very High
ketamine 2 100.00 Very High Very High Very High
Paracetamol 25 99.84 Very High Very High Very High
Hyperalgesia 2 99.64 Very High Very High Very High
cINOD 2 95.56 Very High Very High Very High
cocaine 2 93.36 High High
methadone 2 92.88 High High
Morphine 2 92.44 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 16 100.00 Very High Very High Very High
Cancer 13 100.00 Very High Very High Very High
Necrosis 10 100.00 Very High Very High Very High
Hyperalgesia 2 99.64 Very High Very High Very High
Hepatotoxicity 7 99.60 Very High Very High Very High
Sepsis 4 98.44 Very High Very High Very High
Endotoxemia 4 98.00 Very High Very High Very High
Injury 4 96.28 Very High Very High Very High
Depression 1 95.04 Very High Very High Very High
Hepatitis 1 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we used two different HD exposure models to determine the in vivo cutaneous response of the inflammatory cytokines interleukin-6 (IL-6), IL-1alpha, IL-1beta and tumor necrosis factor alpha (TNF-alpha), in order to identify a suitable inflammatory biomarker common to both models.
Regulation (response) of IL-1alpha associated with necrosis, inflammation, cancer and cytokine
1) Confidence 0.60 Published 2000 Journal J Appl Toxicol Section Abstract Doc Link 11428647 Disease Relevance 1.04 Pain Relevance 0.44
A potential mechanism for the beneficial effect of heat could be effects on IL-1 alpha and TNF-alpha, important mediators of sepsis and endotoxemia.
Regulation (effects) of IL-1 alpha associated with endotoxemia and sepsis
2) Confidence 0.53 Published 1994 Journal Lymphokine Cytokine Res. Section Abstract Doc Link 7858059 Disease Relevance 0.83 Pain Relevance 0
The effect of elevated plasma corticosterone levels, induced by ketamine-acepromazine anesthesia, on IL-1 alpha responsiveness was also studied in the RIF-1 tumor model.
Regulation (effect) of IL-1 alpha in plasma associated with anesthesia, ketamine and cancer
3) Confidence 0.45 Published 1990 Journal Cancer Res. Section Abstract Doc Link 2369744 Disease Relevance 0.69 Pain Relevance 0.27
The effect of interleukin 1 alpha on acetaminophen-induced hepatotoxicity.
Regulation (effect) of interleukin 1 alpha associated with paracetamol and hepatotoxicity
4) Confidence 0.44 Published 1993 Journal Cytokine Section Title Doc Link 8218930 Disease Relevance 0.19 Pain Relevance 0.46
The role of proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha) and interleukin 1 alpha (IL-1 alpha), on the hepatotoxicity of APAP was examined at 4, 8, 12, and 24 hr following APAP administration.
Spec (examined) Regulation (role) of interleukin 1 alpha associated with necrosis, paracetamol, cancer, hepatotoxicity and cytokine
5) Confidence 0.41 Published 1996 Journal Toxicol Pathol Section Abstract Doc Link 8992608 Disease Relevance 0.66 Pain Relevance 0.74
The role of proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha) and interleukin 1 alpha (IL-1 alpha), on the hepatotoxicity of APAP was examined at 4, 8, 12, and 24 hr following APAP administration.
Spec (examined) Regulation (role) of IL-1 alpha associated with necrosis, paracetamol, cancer, hepatotoxicity and cytokine
6) Confidence 0.41 Published 1996 Journal Toxicol Pathol Section Abstract Doc Link 8992608 Disease Relevance 0.67 Pain Relevance 0.75
In addition, the activity of drugs of abuse was studied on IL-1 alpha and TNF production by activated murine macrophages.
Regulation (studied) of IL-1 alpha in macrophages
7) Confidence 0.41 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8407054 Disease Relevance 0.10 Pain Relevance 0.43
The duration of inflammatory hyperalgesia was shortened in IL-1alphabeta (-/-) mice versus controls in the CFA model.
Regulation (controls) of IL-1alphabeta associated with hyperalgesia and inflammation
8) Confidence 0.18 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16256210 Disease Relevance 1.51 Pain Relevance 1.17

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