INT230378

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.08
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
smooth muscle 2
amygdala 2
thalamus 2
Cnr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 53 100.00 Very High Very High Very High
agonist 97 99.96 Very High Very High Very High
tail-flick 2 99.76 Very High Very High Very High
medulla 2 99.68 Very High Very High Very High
Central nervous system 8 99.34 Very High Very High Very High
amygdala 6 98.78 Very High Very High Very High
Antinociceptive 8 98.04 Very High Very High Very High
Thalamus 178 96.64 Very High Very High Very High
Cannabinoid receptor 41 93.28 High High
Spinal cord 38 90.24 High High
Disease Link Frequency Relevance Heat
Overactive Bladder 25 93.68 High High
Nociception 31 88.08 High High
Pain 58 84.12 Quite High
Neuropathic Pain 121 79.36 Quite High
INFLAMMATION 21 72.44 Quite High
Urological Neuroanatomy 13 66.48 Quite High
Frailty 2 41.12 Quite Low
Hypersensitivity 18 31.48 Quite Low
Post Operative Pain 22 5.00 Very Low Very Low Very Low
Nervous System Injury 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This dichotomy between CB2 and CB1 receptor expression in the CNS has, however, been dispelled by reports of CB2 receptor expression in the brainstem (Van Sickle et al., 2005) and higher brain centres, including the thalamus (Gong et al., 2006) and cerebellum (Ashton et al., 2006) in naïve rats, although their physiological roles are unclear.
Negative_regulation (reports) of Gene_expression (expression) of CB2 receptor in thalamus associated with medulla, thalamus and central nervous system
1) Confidence 0.43 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.35 Pain Relevance 0.76
In other brain regions, such as the amygdala, the antinociceptive effects of intrabasolateral amygdala injection of WIN55212 in formalin and tail-flick tests were abolished by CB1 receptor antagonism but not CB2 receptor antagonism in naïve rats (Hasanein et al., 2007).
Neg (not) Negative_regulation (abolished) of Neg (not) Gene_expression (antagonism) of CB2 receptor in amygdala associated with tail-flick, antinociceptive and amygdala
2) Confidence 0.43 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.43 Pain Relevance 0.74
4) or mixed CB1 and CB2 receptor antagonists followed by saline vehicle on days 14 and 15 (n?
Negative_regulation (mixed) of Gene_expression (antagonists) of CB2 receptor associated with antagonist
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0 Pain Relevance 0.31
Spatiotemporal expression of CB1, CB2 and TRPV1 receptor - Days 12 to 14 of pregnancy
Negative_regulation (Spatiotemporal) of Gene_expression (expression) of CB2
4) Confidence 0.32 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0.04
Lack of a direct effect of CB1/CB2 agonist CP55,940 and the nonselective agonist anandamide on carbachol induced contractions indicated the absence of direct CB mediated functions of isolated detrusor smooth muscle.[34]
Negative_regulation (effect) of Gene_expression (/) of CB2 in smooth muscle associated with agonist and overactive bladder
5) Confidence 0.28 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.31 Pain Relevance 0.25

General Comments

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