INT23045

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Context Info
Confidence 0.64
First Reported 1983
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 19.35
Pain Relevance 4.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Hbb)
Anatomy Link Frequency
blood 4
plasma 2
red blood cell 2
leucocytes 2
liver 1
Hbb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 8 98.80 Very High Very High Very High
anesthesia 23 98.40 Very High Very High Very High
antidepressant 16 96.84 Very High Very High Very High
cva 5 95.92 Very High Very High Very High
Inflammation 219 95.52 Very High Very High Very High
cytokine 34 94.88 High High
nud 1 94.64 High High
Glutamate 74 94.56 High High
depression 51 94.36 High High
Pain 7 94.20 High High
Disease Link Frequency Relevance Heat
Body Weight 98 99.98 Very High Very High Very High
Diabetes Mellitus 279 99.84 Very High Very High Very High
Hypertension 22 99.48 Very High Very High Very High
Ulcers 2 99.28 Very High Very High Very High
Congenital Anomalies 24 98.54 Very High Very High Very High
Cataract 95 98.24 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 11 97.72 Very High Very High Very High
Embolism 1 97.36 Very High Very High Very High
Anaemia 495 97.28 Very High Very High Very High
Thinness 1 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For low-dose WA rats the hematologic changes, including significant increases in red blood cells, white blood cells, hemoglobin, hematocrit, neutrophils, lymphocytes, and monocytes, peaked at 3 months postimplantation and returned to normal by 5–6 months.
Positive_regulation (increases) of hemoglobin in white blood cells
1) Confidence 0.64 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257598 Disease Relevance 0.70 Pain Relevance 0
Rats implanted with 20 WA pellets exhibited significant increases in white blood cell counts, red blood cell counts, hemoglobin, and hematocrit levels compared with Ta control rats, whereas rats implanted with 20 Ni pellets had significant decreases in red blood cell counts, hemoglobin, and hematocrit levels (Table 1).
Positive_regulation (increases) of hemoglobin in red blood cell
2) Confidence 0.64 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257598 Disease Relevance 0.49 Pain Relevance 0
Statistically significant increases in red blood counts, hemoglobin, and hematocrit levels were observed in high-dose WA animals as early as 1 month after pellet implantation and persisted throughout the experimental period (Tables 2 and 3).
Positive_regulation (increases) of hemoglobin in blood
3) Confidence 0.64 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257598 Disease Relevance 0.26 Pain Relevance 0
Body weight increased and plasma glucose and glycosylated hemoglobin were stable in vehicle-treated rats.
Positive_regulation (increased) of hemoglobin in plasma associated with body weight
4) Confidence 0.46 Published 2004 Journal Life Sci. Section Abstract Doc Link 15312754 Disease Relevance 0.52 Pain Relevance 0.69
General linear model analysis was used to extract this component from the time series, and revealed an underlying short-latency increase in deoxygenated hemoglobin in response to somatosensory stimulation.
Positive_regulation (increase) of hemoglobin
5) Confidence 0.46 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 12045665 Disease Relevance 0.09 Pain Relevance 0.21
An experimentally verified computer model predicted a drop in mean endoneurial oxygen tension from 30.5 to 19 mm Hg, despite a measured increase in circulating hemoglobin from 16 to 22 g%.
Positive_regulation (increase) of hemoglobin
6) Confidence 0.46 Published 1987 Journal Brain Res. Section Abstract Doc Link 2445441 Disease Relevance 0.49 Pain Relevance 0.07
The results were as follows: 1) The same tendencies were noted in blood constituents between male and female rats in the control group and the tail suspension group. 2) The average levels of blood albumin, creatinine, uric acid, glucose, triglyceride, serum iron and hemoglobin in the tail suspension group were lower than those in the control group, especially in male rats.
Positive_regulation (lower) of hemoglobin in tail
7) Confidence 0.36 Published 1990 Journal Physiologist Section Abstract Doc Link 2371312 Disease Relevance 0.08 Pain Relevance 0.08
Here we report that the administration of hydroxyurea, an antitumor drug, to rats at pharmacological doses formed detectable nitrosyl hemoglobin, which increased with dose.
Positive_regulation (increased) of hemoglobin
8) Confidence 0.30 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9415718 Disease Relevance 0.09 Pain Relevance 0.04
Increases in various ulcerogenic parameters, such as gastric acid back-diffusion, mucosal histamine concentration, luminal hemoglobin (Hb) content and stomach ulcer, were dependent on the concentration of acid solutions irrigated in stomachs of those LPS rats.
Positive_regulation (Increases) of hemoglobin in stomachs associated with ulcers
9) Confidence 0.25 Published 2001 Journal Chin J Physiol Section Abstract Doc Link 11908549 Disease Relevance 0.17 Pain Relevance 0.09
For low-dose WA rats the hematologic changes, including significant increases in red blood cells, white blood cells, hemoglobin, hematocrit, neutrophils, lymphocytes, and monocytes, peaked at 3 months postimplantation and returned to normal by 5–6 months.
Positive_regulation (increases) of hemoglobin in red blood cells
10) Confidence 0.22 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257598 Disease Relevance 0.70 Pain Relevance 0
Exposure of rats to a simulated altitude of 5,000 m for 1 and 3 d caused increases in hematocrit (Hct) and in hemoglobin (Hb) concentration and a decrease in total plasma volume (TPV) in comparison with sea level control animals.
Positive_regulation (increases) of hemoglobin in plasma
11) Confidence 0.16 Published 1983 Journal Aviat Space Environ Med Section Abstract Doc Link 6847573 Disease Relevance 0.27 Pain Relevance 0.15
Effects of different factors on cerebral PtO2 were modeled and compared with experimental values obtained with various experimental interventions including: changing CBF, modifying p50 with the allosteric modifier RSR13, modification of capillary density, and hemoglobin content.
Positive_regulation (modifying) of hemoglobin in capillary
12) Confidence 0.13 Published 2005 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 16594142 Disease Relevance 0 Pain Relevance 0
The activities of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase, triglycerides, erythrocyte counts, the packet-cell volume, hemoglobin concentrations and neutrophyle rates significantly increased (p < 0.05 to p < 0.01) after halothane anesthesia and returned to near control levels after Se, vitamin E and Se plus vitamin E injections.
Positive_regulation (increased) of hemoglobin in erythrocyte associated with anesthesia and halothane
13) Confidence 0.12 Published 2003 Journal J Trace Elem Med Biol Section Abstract Doc Link 12755499 Disease Relevance 0.36 Pain Relevance 0.57
In a study with sertraline, glycosylated hemoglobin (HbA1c) levels were reduced during treatment, but did not differ between the sertraline and placebo groups,15,16 whereas no significant reduction in HbA1c levels was observed in patients treated with fluoxetine or paroxetine, although their depressive symptoms were significantly improved.17 Similarly, although escitalopram resulted in a significant reduction of depression score, there was only a small and nonsignificant reduction in fasting blood glucose (FBG) levels and HbA1c levels.18 It would thus appear that selective serotonin reuptake inhibitors (SSRIs) do not have any major effect on metabolic control, even when they produce a significant effect on depressive symptoms.
Positive_regulation (glycosylated) of hemoglobin in blood associated with depression, ssri and fluoxetine
14) Confidence 0.05 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2819761 Disease Relevance 1.92 Pain Relevance 0.72
Alloxan diabetic rats showed significant elevation in the blood glucose, glycosylated hemoglobin and serum lipid levels while the serum insulin, total protein and liver glycogen levels were decreased significantly in comparison to normal rats.
Positive_regulation (elevation) of hemoglobin in blood associated with diabetes mellitus
15) Confidence 0.04 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC2048984 Disease Relevance 0.66 Pain Relevance 0.09
Glycosylated hemoglobin levels (% HbA1c) were significantly increased in diabetic animals compared to controls as well (Experiments 3 & 4).
Positive_regulation (increased) of hemoglobin associated with diabetes mellitus
16) Confidence 0.02 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.96 Pain Relevance 0.03
In patients using rofecoxib there was also observed an increase in the activity of liver enzymes ALAT, ASPAT, and decrease in hematocrit value, the number of erythrocytes, hemoglobin and leucocytes.
Positive_regulation (increase) of hemoglobin in leucocytes
17) Confidence 0.02 Published 2010 Journal Protoplasma Section Body Doc Link PMC2947012 Disease Relevance 1.16 Pain Relevance 0.21
In adult hemodialysis patients on maintenance intravenous iron sucrose therapy, intravenous administration of 500 mg ascorbic acid three times a week for 6 months resulted in an increase of TSAT and hemoglobin in approximately 65% of the patients [90].
Positive_regulation (increase) of hemoglobin
18) Confidence 0.02 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC1805051 Disease Relevance 0.51 Pain Relevance 0.05
Hemoglobin levels increase with an increase of IL-4 and a decrease of TNF-?
Positive_regulation (increase) of Hemoglobin
19) Confidence 0.02 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC1805051 Disease Relevance 0.44 Pain Relevance 0.22
By these mechanisms, in addition to its well-known stimulatory effects on erythropoiesis, iron therapy contributes to an increase in hemoglobin levels and to a decrease in the need of ESAs.
Positive_regulation (increase) of hemoglobin
20) Confidence 0.02 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC1805051 Disease Relevance 0.64 Pain Relevance 0.26

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