INT230461

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.06
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR1, TLR2) plasma membrane (TLR1, TLR2) intracellular (TLR1, TLR2)
cytoplasm (TLR2)
TLR1 (Homo sapiens)
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 34 88.32 High High
Inflammatory response 28 87.44 High High
ischemia 3 83.36 Quite High
chemokine 3 74.48 Quite High
Inflammation 23 65.16 Quite High
tolerance 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 10 99.64 Very High Very High Very High
Obesity 6 98.20 Very High Very High Very High
Atherosclerosis 8 97.08 Very High Very High Very High
Shock 2 93.28 High High
INFLAMMATION 53 87.04 High High
Injury 3 84.16 Quite High
Cv Unclassified Under Development 3 83.36 Quite High
Myocardial Infarction 4 80.80 Quite High
Alzheimer's Dementia 1 78.20 Quite High
Multibacillary Leprosy 4 73.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although no distinction was made among the TLR dimers in the report, TLR1/TLR2 heterodimer was most likely responsible for the recognition of the cell wall extract of S. aureus.
TLR1 Binding (heterodimer) of TLR2
1) Confidence 0.33 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.09 Pain Relevance 0.09
Although no distinction was made among the TLR dimers in the report, TLR1/TLR2 heterodimer was most likely responsible for the recognition of the cell wall extract of S. aureus.
TLR1 Binding (heterodimer) of TLR2
2) Confidence 0.33 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.09 Pain Relevance 0.09
TLR2 (Online Mendelian Inheritancce in Man (OMIM):603028), as a heterodimer with TLR1 (OMIM: 601194) or TLR6 (OMIM: 605403), mediates recognition of several mycobacterial motifs, including lipopeptides, the 19 kDa protein, lipoarabinomannan (LAM) [1],[27],[28].
TLR1 Binding (heterodimer) of TLR2
3) Confidence 0.26 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2330092 Disease Relevance 0.98 Pain Relevance 0.18
TLR2 (in a heterodimeric association with TLR1 or TLR6) recognizes certain lipopeptides, peptidoglycans, and other lipid moieties derived from gram-positive bacteria (5).
TLR1 Binding (association) of TLR2
4) Confidence 0.09 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.91 Pain Relevance 0.07

General Comments

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