INT230483

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.11
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
reticulum 1
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 10 71.28 Quite High
cytokine 1 70.92 Quite High
Inflammation 6 70.52 Quite High
fibrosis 2 68.52 Quite High
tolerance 22 47.88 Quite Low
Chronic pancreatitis 10 5.00 Very Low Very Low Very Low
Cholecystokinin 5 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 21 85.68 High High
Insulin Resistance 11 83.44 Quite High
Diabetes Mellitus 28 82.28 Quite High
INFLAMMATION 8 70.52 Quite High
Fibrosis 2 68.52 Quite High
Shock 4 63.48 Quite High
Pancreatitis 47 52.28 Quite High
Pancreatic Cancer 17 52.08 Quite High
Alcoholic Pancreatitis 4 50.00 Quite Low
Pancreatic Ductal Carcinoma 1 49.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
g/mL, ellagic acid inhibited PDGF-induced tyrosine phosphorylation of PDGF ß-receptor and the activation of the downstream signalling pathways (extracellular signal-regulated protein kinase and Akt).
Protein_catabolism (protein) of Akt
1) Confidence 0.10 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872306 Disease Relevance 0.43 Pain Relevance 0.20
HSP90 is expressed in the cytosol, nucleus and endoplasmic reticulum [9] and has several physiological roles, including mediating tyrosine kinase receptor maturation and protein kinase B (PKB/AKT) stability, an important activator of glucose transports systems [9,10].
Protein_catabolism (stability) of protein kinase B in reticulum
2) Confidence 0.08 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.68 Pain Relevance 0

General Comments

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