INT230492

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.92
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
band 2
parenchyma 2
Meta (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 27 100.00 Very High Very High Very High
cytokine 14 100.00 Very High Very High Very High
chemokine 7 100.00 Very High Very High Very High
Potency 31 99.80 Very High Very High Very High
glial activation 1 74.60 Quite High
antagonist 37 72.92 Quite High
Central nervous system 34 65.52 Quite High
Inflammatory mediators 1 63.16 Quite High
Inflammatory response 3 17.04 Low Low
tolerance 3 16.96 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 31 100.00 Very High Very High Very High
Adhesions 4 100.00 Very High Very High Very High
Hypertrophy 1 79.12 Quite High
Injury 36 71.44 Quite High
Disease 25 66.40 Quite High
Targeted Disruption 19 61.76 Quite High
Penetrating Head Injuries 1 56.88 Quite High
Necrosis 2 56.08 Quite High
Cancer 2 55.72 Quite High
Alzheimer's Dementia 62 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in rodents increases expression of pro-inflammatory cytokines, leukocyte chemotactic chemokines, cell surface adhesion molecules, cyclooxygenases and matrix metalloproteases within the brain parenchyma [40-45].
Positive_regulation (increases) of Gene_expression (expression) of meta in parenchyma associated with chemokine, inflammation, adhesions and cytokine
1) Confidence 0.45 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.92 Pain Relevance 0.44
This spectrum is very similar to the corresponding double difference spectrum of wildtype (green spectrum) obtained under conditions where wildtype Meta III adopts a similarly active conformation (pH 4.0).35 The mutant spectrum reveals a pronounced Meta III band at 1565 cm? 
Positive_regulation (pronounced) of Gene_expression (band) of Meta in band
2) Confidence 0.18 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0
On the left hand aromatic ring of the structure, substitution in both the ortho and meta positions with either halogen or CF3 groups was a definite requirement for potency.
Positive_regulation (requirement) of Gene_expression (positions) of meta associated with potency
3) Confidence 0.03 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox