INT230493

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.89
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Alms1) cilium (Alms1) molecular_function (Alms1)
lipid metabolic process (Alms1) cytoplasm (Alms1)
Anatomy Link Frequency
leukocytes 2
neutrophil 2
Alms1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 28 98.38 Very High Very High Very High
Multiple sclerosis 89 94.96 High High
Central nervous system 57 85.76 High High
Inflammation 85 83.36 Quite High
Potency 2 76.96 Quite High
chemokine 42 40.20 Quite Low
Inflammatory response 2 34.08 Quite Low
long-term potentiation 3 27.12 Quite Low
ischemia 5 15.40 Low Low
5HT 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rodent Diseases 1 99.36 Very High Very High Very High
Multiple Sclerosis 146 97.88 Very High Very High Very High
Disease 70 94.36 High High
INFLAMMATION 91 83.36 Quite High
Malignant Neoplastic Disease 1 77.92 Quite High
Atherosclerotic Plaque 2 75.68 Quite High
Nervous System Injury 1 72.16 Quite High
Thrombocytopenia 5 71.44 Quite High
Recurrence 2 65.44 Quite High
Targeted Disruption 15 64.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
New developments in high field strength MRI and novel contrast media provide optimized means to detect lesions and localize alterations in BBB integrity, even in small rodent disease models such as murine EAE [8].
Regulation (alterations) of BBB Binding (integrity) of associated with multiple sclerosis, rodent diseases and imagery
1) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 1.10 Pain Relevance 0.45
can influence BBB integrity even in the relative absence of neutrophil recruitment.
Regulation (influence) of BBB Binding (integrity) of in neutrophil
2) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.18 Pain Relevance 0.10
Our findings, together with evidence reviewed in prior sections, suggest a broader hypothesis, namely, that platelet interaction with leukocytes at the endothelium of the BBB is responsible for the release of PECAM-1 to the circulation, and associated infiltration of leukocytes.
Regulation (responsible) of BBB Binding (interaction) of in leukocytes
3) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.61 Pain Relevance 0.21

General Comments

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