INT230497

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.77
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
knee joints 2
brain 2
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 34 99.48 Very High Very High Very High
Arthritis 82 99.02 Very High Very High Very High
ischemia 4 98.92 Very High Very High Very High
Inflammation 59 95.64 Very High Very High Very High
cytokine 27 53.76 Quite High
Inflammatory response 6 50.00 Quite Low
antagonist 5 41.32 Quite Low
agonist 30 25.00 Low Low
chemokine 15 5.00 Very Low Very Low Very Low
rheumatoid arthritis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 34 99.62 Very High Very High Very High
Arthritis 41 99.02 Very High Very High Very High
Cv Unclassified Under Development 4 98.92 Very High Very High Very High
Experimental Arthritis 49 98.42 Very High Very High Very High
Infection 3 97.88 Very High Very High Very High
Brain Injury 9 97.32 Very High Very High Very High
Stroke 2 95.84 Very High Very High Very High
INFLAMMATION 64 95.64 Very High Very High Very High
Disease 32 90.68 High High
Epilepsy 1 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This pattern of expression was further extended to animal models of CNS injury where parenchymal IL-1 mRNA and protein levels are elevated in experimental models of ischemia, excitotoxicity, infection and traumatic brain injury in rodents.
Positive_regulation (elevated) of Transcription (levels) of IL-1 in brain associated with ischemia, injury, central nervous system, brain injury and infection
1) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.73 Pain Relevance 0.29
In CIA, an increase in the arthritis score of the knee joints was associated with an increase in IL-1 mRNA levels [33].
Positive_regulation (increase) of Transcription (levels) of IL-1 in knee joints associated with arthritis
2) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.04 Pain Relevance 0.48

General Comments

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